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Science 18 July 1986:
Vol. 233. no. 4761, pp. 364 - 367
DOI: 10.1126/science.3014653
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Articles

Science, Vol 233, Issue 4761, 364-367
Copyright © 1986 by American Association for the Advancement of Science

articles

Human prion protein cDNA: molecular cloning, chromosomal mapping, and biological implications

YC Liao, RV Lebo, GA Clawson, and EA Smuckler

A human complementary DNA whose protein product is considered to be the major component of scrapie-associated fibrils in Creutzfeldt-Jakob disease, kuru, and Gerstmann-Straussler syndrome has been identified and characterized. The extensive homology of this gene sequence to the hamster PrP 27- to 30-kilodalton prion protein complementary DNA clone, and its existence as a single copy in the human genome, leads to the conclusion that this is the human prion gene. This human prion gene has been mapped to human chromosome 20, negating a direct link between the prion protein and Down's syndrome or the amyloid of Alzheimer's disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A High-Throughput Drug Screen Targeted to the 5'Untranslated Region of Alzheimer Amyloid Precursor Protein mRNA.
S. Bandyopadhyay, J. Ni, A. Ruggiero, K. Walshe, M. S. Rogers, N. Chattopadhyay, M. A. Glicksman, and J. T. Rogers (2006)
J Biomol Screen 11, 469-480
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Identification of Novel Proteinase K-resistant C-terminal Fragments of PrP in Creutzfeldt-Jakob Disease.
W.-Q. Zou, S. Capellari, P. Parchi, M.-S. Sy, P. Gambetti, and S. G. Chen (2003)
J. Biol. Chem. 278, 40429-40436
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An Orthodox Heresy: Scientific Rhetoric and the Science of Prions.
C. Reeves (2002)
Science Communication 24, 98-122
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Lingering Doubts about Spongiform Encephalopathy and Creutzfeldt-Jakob Disease.
H. K. Narang (2001)
Experimental Biology and Medicine 226, 640-652
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Effect of the E200K Mutation on Prion Protein Metabolism : Comparative Study of a Cell Model and Human Brain.
S. Capellari, P. Parchi, C. M. Russo, J. Sanford, M.-S. Sy, P. Gambetti, and R. B. Petersen (2000)
Am. J. Pathol. 157, 613-622
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Prion Protein Structure and Scrapie Replication: Theoretical, Spectroscopic, and Genetic Investigations.
P. Bamborough, H. Wille, G.C. Telling, F. Yehiely, S.B. Prusiner, and F.E. Cohen (1996)
Cold Spring Harb Symp Quant Biol 61, 495-509
   Abstract »    PDF »
Truncated Forms of the Human Prion Protein in Normal Brain and in Prion Diseases.
S. G. Chen, D. B. Teplow, P. Parchi, J. K. Teller, P. Gambetti, and L. Autilio-Gambetti (1995)
J. Biol. Chem. 270, 19173-19180
   Abstract »    Full Text »    PDF »
Molecular biology of prion diseases.
S. Prusiner (1991)
Science 252, 1515-1522
   Abstract »    PDF »
Spontaneous neurodegeneration in transgenic mice with mutant prion protein.
K. Hsiao, M Scott, D Foster, D. Groth, S. DeArmond, and S. Prusiner (1990)
Science 250, 1587-1590
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