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Science 27 June 1986:
Vol. 232. no. 4758, pp. 1632 - 1635
DOI: 10.1126/science.3715469
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Articles

Science, Vol 232, Issue 4758, 1632-1635
Copyright © 1986 by American Association for the Advancement of Science

articles

High resolution of mouse chromosomes: banding conservation between man and mouse

Sawyer JR and JC Hozier

A detailed schematic representation of high-resolution G-banding patterns was prepared from elongated and finely banded mitotic chromosomes of the mouse. Such chromosomes can be obtained from both animal tissue and cell lines by a simple protocol, facilitating precise demarcation of breakpoints in chromosome rearrangements and aiding in the sublocalization of genes. Regions of subbanding homology were observed between human and mouse chromosomal segments known to have conserved gene assignments, an indication that, at the cytogenetic level, extensive regions of the mammalian genome may remain intact after 60 million years of species divergence.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Automated Construction of High-Density Comparative Maps Between Rat, Human, and Mouse.
A. E. Kwitek, P. J. Tonellato, D. Chen, J. Gullings-Handley, Y. S. Cheng, S. Twigger, T. E. Scheetz, T. L. Casavant, M. Stoll, M. A. Nobrega, et al. (2001)
Genome Res. 11, 1935-1943
   Abstract »    Full Text »    PDF »
Amplification of the Transketolase Gene in Desensitization-resistant Mutant Y1 Mouse Adrenocortical Tumor Cells.
B. P. Schimmer, J. Tsao, and W. Czerwinski (1996)
J. Biol. Chem. 271, 4993-4998
   Abstract »    Full Text »    PDF »


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