Science 6 June 1986: Vol. 232. no. 4755, pp. 1250 - 1253 DOI: 10.1126/science.2422759

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Articles

Analytic Review: The Pathogenetic and Prognostic Value of Biologic Markers in Acute Lung Injury.

J. E. Levitt, M. K. Gould, L. B. Ware, and M. A. Matthay (2009)
J Intensive Care Med 24, 151-167
 |  Abstract »  |  PDF »

A review of molecular pathological markers in vulvar carcinoma: lack of application in clinical practice.

S Knopp, C Trope, J M Nesland, and R Holm (2009)
J. Clin. Pathol. 62, 212-218
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Erlotinib in Pancreatic Cancer Patients: Do We Need More Information From the NCIC CTG Trial?.

M. Mandala, C. Moro, R. Labianca, and G. Ferretti (2007)
J. Clin. Oncol. 25, 4320-4321
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Biology of Interactions: Antiepidermal Growth Factor Receptor Agents.

P. M. Harari, G. W. Allen, and J. A. Bonner (2007)
J. Clin. Oncol. 25, 4057-4065
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Consequences of Direct Versus Indirect Activation of Epidermal Growth Factor Receptor in Intestinal Epithelial Cells Are Dictated by Protein-tyrosine Phosphatase 1B.

D. F. McCole, A. Truong, M. Bunz, and K. E. Barrett (2007)
J. Biol. Chem. 282, 13303-13315
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Epidermal growth factor released in human dental pulp following orthodontic force.

K. Derringer and R. Linden (2007)
Eur J Orthod 29, 67-71
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Molecular Mechanisms of Epidermal Growth Factor Receptor (EGFR) Activation and Response to Gefitinib and Other EGFR-Targeting Drugs.

M. Ono and M. Kuwano (2006)
Clin. Cancer Res. 12, 7242-7251
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Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis.

B. Kaur, F. W. Khwaja, E. A. Severson, S. L. Matheny, D. J. Brat, and E. G. Van Meir (2005)
Neuro-oncol 7, 134-153
 |  Abstract »  |  PDF »

Cetuximab, a Monoclonal Antibody Targeting the Epidermal Growth Factor Receptor, in Combination With Gemcitabine for Advanced Pancreatic Cancer: A Multicenter Phase II Trial.

H. Q. Xiong, A. Rosenberg, A. LoBuglio, W. Schmidt, R. A. Wolff, J. Deutsch, M. Needle, and J. L. Abbruzzese (2004)
J. Clin. Oncol. 22, 2610-2616
 |  Abstract »  |  Full Text »  |  PDF »

Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-{alpha}.

T. D. Le Cras, W. D. Hardie, K. Fagan, J. A. Whitsett, and T. R. Korfhagen (2003)
Am J Physiol Lung Cell Mol Physiol 285, L1046-L1054
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Ligand-induced Lysosomal Epidermal Growth Factor Receptor (EGFR) Degradation Is Preceded by Proteasome-dependent EGFR De-ubiquitination.

H. A. J. Alwan, E. J. J. van Zoelen, and J. E. M. van Leeuwen (2003)
J. Biol. Chem. 278, 35781-35790
 |  Abstract »  |  Full Text »  |  PDF »

Changes of Messenger RNA Expression of Angiogenic Factors and Related Receptors During Follicular Development in Gilts.

T. Shimizu, J.-Y. Jiang, H. Sasada, and E. Sato (2002)
Biol Reprod 67, 1846-1852
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Enhanced Antiangiogenic Therapy of Squamous Cell Carcinoma by Combined Endostatin and Epidermal Growth Factor Receptor-Antisense Therapy.

M. Li, C. Ye, C. Feng, F. Riedel, X. Liu, Q. Zeng, and J. R. Grandis (2002)
Clin. Cancer Res. 8, 3570-3578
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of Epidermal Growth Factor Receptor Signaling on Tumor Cells and Tumor-Associated Endothelial Cells for Therapy of Human Carcinomas.

C. H. Baker, D. Kedar, M. F. McCarty, R. Tsan, K. L. Weber, C. D. Bucana, and I. J. Fidler (2002)
Am. J. Pathol. 161, 929-938
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling for Therapy of Metastatic Human Pancreatic Cancer.

C. H. Baker, C. C. Solorzano, and I. J. Fidler (2002)
Cancer Res. 62, 1996-2003
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Transforming Growth Factor {beta}1 (TGF-{beta}1) Promotes Endothelial Cell Survival during In Vitro Angiogenesis via an Autocrine Mechanism Implicating TGF-{alpha} Signaling.

F. Vinals and J. Pouyssegur (2001)
Mol. Cell. Biol. 21, 7218-7230
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Optimization for the Blockade of Epidermal Growth Factor Receptor Signaling for Therapy of Human Pancreatic Carcinoma.

C. C. Solorzano, C. H. Baker, R. Tsan, P. Traxler, P. Cohen, E. Buchdunger, J. J. Killion, and I. J. Fidler (2001)
Clin. Cancer Res. 7, 2563-2572
 |  Abstract »  |  Full Text »  |  PDF »

Teratogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Mice Lacking the Expression of EGF and/or TGF-{{alpha}}.

P. L. Bryant, J. E. Schmid, S. E. Fenton, A. R. Buckalew, and B. D. Abbott (2001)
Toxicol. Sci. 62, 103-114
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Gene Therapy Targeting for Hepatocellular Carcinoma: Selective and Enhanced Suicide Gene Expression Regulated by a Hypoxia-inducible Enhancer Linked to a Human {{alpha}}-Fetoprotein Promoter.

A. Ido, H. Uto, A. Moriuchi, K. Nagata, Y. Onaga, M. Onaga, T. Hori, S. Hirono, K. Hayashi, T. Tamaoki, et al. (2001)
Cancer Res. 61, 3016-3021
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Bcl-2 Delays and Alters Hepatic Carcinogenesis Induced by Transforming Growth Factor {{alpha}}.

M. E. Vail, R. H. Pierce, and N. Fausto (2001)
Cancer Res. 61, 594-601
 |  Abstract »  |  Full Text »

The Egr-1 gene is induced by epidermal growth factor in ECV304 cells and primary endothelial cells.

J. C. Tsai, L. Liu, J. Guan, and W. C. Aird (2000)
Am J Physiol Cell Physiol 279, C1414-C1424
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Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium.

L.L. Nikitenko, I.Z. MacKenzie, M.C.P. Rees, and R. Bicknell (2000)
Mol. Hum. Reprod. 6, 811-819
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Blockade of the Epidermal Growth Factor Receptor Signaling by a Novel Tyrosine Kinase Inhibitor Leads to Apoptosis of Endothelial Cells and Therapy of Human Pancreatic Carcinoma.

C. J. Bruns, C. C. Solorzano, M. T. Harbison, S. Ozawa, R. Tsan, D. Fan, J. Abbruzzese, P. Traxler, E. Buchdunger, R. Radinsky, et al. (2000)
Cancer Res. 60, 2926-2935
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Receptor Blockade with C225 Plus Gemcitabine Results in Regression of Human Pancreatic Carcinoma Growing Orthotopically in Nude Mice by Antiangiogenic Mechanisms.

C. J. Bruns, M. T. Harbison, D. W. Davis, C. A. Portera, R. Tsan, D. J. McConkey, D. B. Evans, J. L. Abbruzzese, D. J. Hicklin, and R. Radinsky (2000)
Clin. Cancer Res. 6, 1936-1948
 |  Abstract »  |  Full Text »  |  PDF »

In Vivo Enhancement of Tumor Radioresponse by C225 Antiepidermal Growth Factor Receptor Antibody.

L. Milas, K. Mason, N. Hunter, S. Petersen, M. Yamakawa, K. Ang, J. Mendelsohn, and Z. Fan (2000)
Clin. Cancer Res. 6, 701-708
 |  Abstract »  |  Full Text »

Does Cartilage Down-regulate Growth Factor Expression in Tracheal Epithelium?.

W. Hicks Jr, L. Sigurdson, E. Gabalski, R. Hard, L. Hall III, J. Gardella, C. Powers, N. Kumar, and J. Lwebuga-Mukasa (1999)
Arch Otolaryngol Head Neck Surg 125, 1239-1243
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-alpha Deficiency Reduces Pulmonary Fibrosis in Transgenic Mice.

D. K. Madtes, A. L. Elston, R. C. Hackman, A. R. Dunn, and J. G. Clark (1999)
Am. J. Respir. Cell Mol. Biol. 20, 924-934
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Activation of the Mitogen-Activated Protein Kinase Cascade Is Necessary But Not Sufficient for Basic Fibroblast Growth Factor- and Epidermal Growth Factor-Stimulated Expression of Endothelial Nitric Oxide Synthase in Ovine Fetoplacental Artery Endothelial Cells.

J. Zheng, I. M. Bird, A. N. Melsaether, and R. R. Magness (1999)
Endocrinology 140, 1399-1407
 |  Abstract »  |  Full Text »

Tissue Macrophages Associated with Angiogenesis in Chronic Airway Inflammation in Rats.

A. Dahlqvist, E. Y. Umemoto, J. J. Brokaw, M. Dupuis, and D. M. McDonald (1999)
Am. J. Respir. Cell Mol. Biol. 20, 237-247
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Induction of adenocarcinoma from hamster pancreatic islet cells treated with N-nitrosobis(2-oxopropyl)amine in vitro.

B. Schmied, G. Liu, M.P. Moyer, I.S.B. Hernberg, W. Sanger, S. Batra, and P. M. Pour (1999)
Carcinogenesis 20, 317-324
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Manipulation of the angiopoietic/hemangiopoietic commitment in the avian embryo.

L Pardanaud and F Dieterlen-Lievre (1999)
Development 126, 617-627
 |  Abstract »  |  PDF »

Removal of the Membrane-anchoring Domain of Epidermal Growth Factor Leads to Intracrine Signaling and Disruption of Mammary Epithelial Cell Organization.

H. S. Wiley, M. F. Woolf, L. K. Opresko, P. M. Burke, B. Will, J. R. Morgan, and D. A. Lauffenburger (1998)
J. Cell Biol. 143, 1317-1328
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Elevated Transforming Growth Factor-alpha Levels in Bronchoalveolar Lavage Fluid of Patients with Acute Respiratory Distress Syndrome.

D. K. MADTES, G. RUBENFELD, L. D. KLIMA, J. A. MILBERG, K. P. STEINBERG, T. R. MARTIN, G. RAGHU, L. D. HUDSON, and J. G. CLARK (1998)
Am. J. Respir. Crit. Care Med. 158, 424-430
 |  Abstract »  |  Full Text »  |  PDF »

IL-4-Dependent Regulation of TGF-{alpha} and TGF-{beta}1 Expression in Human Eosinophils.

A. E. Elovic, H. Ohyama, A. Sauty, J. McBride, T. Tsuji, M. Nagai, P. F. Weller, and D. T. W. Wong (1998)
J. Immunol. 160, 6121-6127
 |  Abstract »  |  Full Text »  |  PDF »

Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency.

H. Waterman, I. Sabanai, B. Geiger, and Y. Yarden (1998)
J. Biol. Chem. 273, 13819-13827
 |  Abstract »  |  Full Text »  |  PDF »

Epiregulin Is a Potent Pan-ErbB Ligand That Preferentially Activates Heterodimeric Receptor Complexes.

M. Shelly, R. Pinkas-Kramarski, B. C. Guarino, H. Waterman, L.-M. Wang, L. Lyass, M. Alimandi, A. Kuo, S. S. Bacus, J. H. Pierce, et al. (1998)
J. Biol. Chem. 273, 10496-10505
 |  Abstract »  |  Full Text »  |  PDF »

BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis.

T. D. Piscione, T. D. Yager, I. R. Gupta, B. Grinfeld, Y. Pei, L. Attisano, J. L. Wrana, and N. D. Rosenblum (1997)
Am J Physiol Renal Physiol 273, F961-F975
 |  Abstract »  |  Full Text »  |  PDF »

Human Monocytes and Neutrophils Store Transforming Growth Factor-alpha in a Subpopulation of Cytoplasmic Granules.

J. Calafat, H. Janssen, M. S. hle-Backdahl, A. E.M. Zuurbier, E. F. Knol, and A. Egesten (1997)
Blood 90, 1255-1266
 |  Abstract »  |  Full Text »  |  PDF »

Transcription Factor AP-2 Controls Transcription of the Human Transforming Growth Factor-alpha Gene.

D. Wang, T. H. Shin, and J. E. Kudlow (1997)
J. Biol. Chem. 272, 14244-14250
 |  Abstract »  |  Full Text »  |  PDF »

The Significance of Valine 33as a Ligand-specific Epitope of Transforming Growth Factor alpha.

S. M. Puddicombe, S. G. Chamberlin, J. MacGarvie, A. Richter, D. R. Drummond, J. Collins, L. Wood, and D. E. Davies (1996)
J. Biol. Chem. 271, 15367-15372
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

S. Frank, G. Hübner, G. Breier, M. T. Longaker, D. G. Greenhalgh, and S. Werner (1995)
J. Biol. Chem. 270, 12607-12613
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-alpha Abrogates Glucocorticoid-stimulated Tight Junction Formation and Growth Suppression in Rat Mammary Epithelial Tumor Cells.

P. Buse, P. L. Woo, D. B. Alexander, H. H. Cha, A. Reza, N. D. Sirota, and G. L. Firestone (1995)
J. Biol. Chem. 270, 6505-6514
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Trafficking of Epidermal Growth Factor Family Ligands Is Directly Influenced by the pH Sensitivity of the Receptor/Ligand Interaction.

A. R. French, D. K. Tadaki, S. K. Niyogi, and D. A. Lauffenburger (1995)
J. Biol. Chem. 270, 4334-4340
 |  Abstract »  |  Full Text »  |  PDF »

TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes.

L. Reneker, D. Silversides, K Patel, and P. Overbeek (1995)
Development 121, 1669-1680
 |  Abstract »  |  PDF »

The Pathophysiology of Angiogenesis.

P.J. Polverini (1995)
Critical Reviews in Oral Biology & Medicine 6, 230-247
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor, Transforming Growth Factor-{alpha}, and Epidermal Growth Factor Receptor Localization in the Baboon (Papio anubis) Uterus During the Menstrual Cycle and Early Pregnancy.

M. J. Slowey, H. G. Verhage, and A. T. Fazleabas (1994)
Reproductive Sciences 1, 277-284
 |  Abstract »  |  PDF »

Therapeutic Angiogenesis.

M. Hockel, K. Schlenger, S. Doctrow, T. Kissel, and P. Vaupel (1993)
Arch Surg 128, 423-429
 |  Abstract »  |  PDF »

Transforming Growth Factor {alpha} Expression Helps to Distinguish Keratoacanthomas From Squamous Cell Carcinomas.

T. Ho, T. Horn, and E. Finzi (1991)
Arch Dermatol 127, 1167-1171
 |  Abstract »  |  PDF »

Mesenchymal Cell Growth Factors.

D. T. Graves and D. L. Cochran (1990)
Critical Reviews in Oral Biology & Medicine 1, 17-36
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Interaction between The Neural Crest and Extracellular Matrix Proteins in Craniofacial Skeletogenesis.

M. Mina, E. J. Kollar, J. A. Bishop, and D. H. Rohrbach (1990)
Critical Reviews in Oral Biology & Medicine 1, 79-87
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Vascular endothelial growth factor is a secreted angiogenic mitogen.

D. Leung, G Cachianes, W. Kuang, D. Goeddel, and N Ferrara (1989)
Science 246, 1306-1309
 |  Abstract »  |  PDF »

Overexpression of transforming growth factor alpha in psoriatic epidermis.

J. Elder, G. Fisher, P. Lindquist, G. Bennett, M. Pittelkow, R. Coffey Jr, L Ellingsworth, R Derynck, and J. Voorhees (1989)
Science 243, 811-814
 |  Abstract »  |  PDF »

Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping.

D. Rappolee, D Mark, M. Banda, and Z Werb (1988)
Science 241, 708-712
 |  Abstract »  |  PDF »

Extracellular Modulating Factors and the Control of Intraocular Neovascularization: An Overview.

B. M. Glaser (1988)
Arch Ophthalmol 106, 603-607
 |  Abstract »  |  PDF »

Tissue distribution and developmental expression of the messenger RNA encoding angiogenin.

H. Weiner, L. Weiner, and J. Swain (1987)
Science 237, 280-282
 |  Abstract »  |  PDF »

Chemical identification of a tumor-derived angiogenic factor.

F. Kull Jr, D. Brent, I Parikh, and P Cuatrecasas (1987)
Science 236, 843-845
 |  Abstract »  |  PDF »

Angiogenic factors.

J Folkman and M Klagsbrun (1987)
Science 235, 442-447
 |  Abstract »  |  PDF »

Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor.

G. Schultz, M White, R Mitchell, G Brown, J Lynch, D. Twardzik, and G. Todaro (1987)
Science 235, 350-352
 |  Abstract »  |  PDF »

Endogeneous and Heterologous Expression of Transforming Growth Factor-{alpha} in Mammalian Cells.

R. Derynck, A. Rosenthal, P.B. Lindquist, T.S. Bringman, and D.V. Goeddel (1986)
Cold Spring Harb Symp Quant Biol 51, 649-655
 |  Abstract »  |  PDF »

Cloning and Biological Activity of Epigen, a Novel Member of the Epidermal Growth Factor Superfamily.

L. Strachan, J. G. Murison, R. L. Prestidge, M. A. Sleeman, J. D. Watson, and K. D. Kumble (2001)
J. Biol. Chem. 276, 18265-18271
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of normal and tumor-derived angiogenesis.

M. Papetti and I. M. Herman (2002)
Am J Physiol Cell Physiol 282, C947-C970
 |  Abstract »  |  Full Text »  |  PDF »

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