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Science 23 May 1986:
Vol. 232. no. 4753, pp. 988 - 990
DOI: 10.1126/science.3010459
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Articles

Science, Vol 232, Issue 4753, 988-990
Copyright © 1986 by American Association for the Advancement of Science

articles

Associative induction of posttetanic and long-term potentiation in CA1 neurons of rat hippocampus

BR Sastry, JW Goh, and A Auyeung

Electrical stimulation of fibers in the stratum radiatum causes an excitatory postsynaptic potential in CA1 neurons of the hippocampus. Other excitatory inputs to or direct depolarization of these CA1 neurons during stimulation of the stratum radiatum caused a subsequent increase in the excitatory postsynaptic potential. This enhancement was characterized as a brief potentiation (2 to 3 minutes, similar to posttetanic potentiation) and a long-term potentiation (presumed to be involved in learning and memory). These potentiations are probably induced by an interaction of the postsynaptic cell or other presynaptic terminals with the test presynaptic terminals.


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