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Science 16 May 1986:
Vol. 232. no. 4752, pp. 875 - 877
DOI: 10.1126/science.2871625
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Articles

Science, Vol 232, Issue 4752, 875-877
Copyright © 1986 by American Association for the Advancement of Science

articles

Differences in adrenergic recognition by pancreatic A and B cells

FC Schuit and DG Pipeleers

The adrenergic control of glucose homeostasis is mediated in part through variations in the release of pancreatic hormones. In this study, purified pancreatic A and B cells were used to identify the recognition and messenger units involved in the adrenergic regulation of glucagon and insulin release. Catecholamines induced beta-adrenergic receptor activity in A cells and alpha 2-adrenergic receptor activity in B cells. The two recognition units provoked opposite variations in the production of cellular cyclic adenosine monophosphate, the beta-adrenergic unit enhancing the nucleotide's permissive effect on amino acid-induced glucagon release and the alpha 2-adrenergic unit inhibiting that upon glucose-induced insulin release. In both cell types, catecholamines interact powerfully with the synergistic control of hormone release by nutrient- and (neuro)hormone-driven messenger systems.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)