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Science 16 May 1986:
Vol. 232. no. 4752, pp. 873 - 875
DOI: 10.1126/science.3704630
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Articles

Science, Vol 232, Issue 4752, 873-875
Copyright © 1986 by American Association for the Advancement of Science

articles

Cloned fragment of the hepatitis delta virus RNA genome: sequence and diagnostic application

KJ Denniston, BH Hoyer, A Smedile, FV Wells, J Nelson, and JL Gerin

Hepatitis delta virus (HDV) is a replication-defective etiological agent of hepatitis that requires hepatitis B virus (HBV) as a helper. A complementary DNA (cDNA) fragment of the RNA genome of HDV was cloned into the plasmid vector pBR322, and the primary nucleotide sequence and predicted protein products of the cDNA fragment were determined. This cloned cDNA fragment has been used as a sensitive radioactive probe for the detection of HDV RNA in the serum of patients with either acute or chronic HDV infections.


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