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Science 4 April 1986:
Vol. 232. no. 4746, pp. 85 - 87
DOI: 10.1126/science.3952501
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Articles

Science, Vol 232, Issue 4746, 85-87
Copyright © 1986 by American Association for the Advancement of Science

articles

Differential conditioning of associative synaptic enhancement in hippocampal brain slices

Kelso SR and TH Brown

An electrophysiological stimulation paradigm similar to one that produces Pavlovian conditioning was applied to synaptic inputs to pyramidal neurons of hippocampal brain slices. Persistent synaptic enhancement was induced in one of two weak synaptic inputs by pairing high-frequency electrical stimulation of the weak input with stimulation of a third, stronger input to the same region. Forward (temporally overlapping) but not backward (temporally separate) pairings caused this enhancement. Thus hippocampal synapses in vitro can undergo the conditional and selective type of associative modification that could provide the substrate for some of the mnemonic functions in which the hippocampus is thought to participate.


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