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Science 4 April 1986:
Vol. 232. no. 4746, pp. 58 - 60
DOI: 10.1126/science.3082008
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Articles

Science, Vol 232, Issue 4746, 58-60
Copyright © 1986 by American Association for the Advancement of Science

articles

Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis

H Darius, DJ Lefer, JB Smith, and AM Lefer

The pathophysiology of anaphylaxis is very complex, and the sequelae of events are not fully explained in terms of the effects of histamine and peptide leukotrienes alone. Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, PAF-acether) has been detected in animals undergoing anaphylaxis. Injection of synthetic PAF-acether induces similar effects, including bronchoconstriction, respiratory arrest, systemic hypotension, neutropenia, and thrombocytopenia. The results reported here demonstrate that the histamine- and leukotriene-independent component of guinea pig anaphylaxis in vivo and in isolated lung parenchymal strips in vitro is mediated by PAF-acether. However, PAF-acether is not responsible for the anaphylaxis-induced thrombocytopenia.


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Role of Platelet-Activating Factor in Cardiovascular Pathophysiology.
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Shock and tissue injury induced by recombinant human cachectin.
K. Tracey, B Beutler, S. Lowry, J Merryweather, S Wolpe, I. Milsark, R. Hariri, T. Fahey 3rd, A Zentella, J. Albert, et al. (1986)
Science 234, 470-474
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Science. ISSN 0036-8075 (print), 1095-9203 (online)