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Science 21 February 1986:
Vol. 231. no. 4740, pp. 854 - 856
DOI: 10.1126/science.3080806
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Articles

Science, Vol 231, Issue 4740, 854-856
Copyright © 1986 by American Association for the Advancement of Science

articles

Mammalian metallothionein is functional in yeast

DJ Thiele, MJ Walling, and DH Hamer

Expression of two monkey metallothioneins in yeast leads to complementation of both known functions of the endogenous yeast copperthionein gene, namely copper detoxification and autoregulation of transcription. The metallothionein-like proteins of higher and lower eukaryotes are therefore functionally analogous despite their dissimilar primary sequences.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Differential Expression of a Metallothionein Gene during the Presymbiotic versus the Symbiotic Phase of an Arbuscular Mycorrhizal Fungus.
L. Lanfranco, A. Bolchi, E. C. Ros, S. Ottonello, and P. Bonfante (2002)
Plant Physiology 130, 58-67
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Haa1, a Protein Homologous to the Copper-regulated Transcription Factor Ace1, Is a Novel Transcriptional Activator.
G. Keller, E. Ray, P. O. Brown, and D. R. Winge (2001)
J. Biol. Chem. 276, 38697-38702
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Disruption of Metallothionein Expression with Antisense Oligonucleotides Abolishes Protection Against Cadmium Cytotoxicity in Molluscan Hemocytes.
R. A. Butler and G. Roesijadi (2001)
Toxicol. Sci. 59, 101-107
   Abstract »    Full Text »    PDF »
A Copper-sensing Transcription Factor Regulates Iron Uptake Genes in Schizosaccharomyces pombe.
S. Labbe, M. M. O. Pena, A. R. Fernandes, and D. J. Thiele (1999)
J. Biol. Chem. 274, 36252-36260
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Superoxide Dismutase Activity Is Essential for Stationary Phase Survival in Saccharomyces cerevisiae.
V. D. Longo, E. B. Gralla, and J. S. Valentine (1996)
J. Biol. Chem. 271, 12275-12280
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Post-transcriptional restriction of gene expression in sea urchin interspecies hybrid embryos..
R A Conlon, F Tufaro, and B P Brandhorst (1987)
Genes & Dev. 1, 337-346
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