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Science 14 February 1986:
Vol. 231. no. 4739, pp. 740 - 742
DOI: 10.1126/science.3753801
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Articles

Science, Vol 231, Issue 4739, 740-742
Copyright © 1986 by American Association for the Advancement of Science

articles

The effects of ivermectin on transmission of Onchocerca volvulus

EW Cupp, MJ Bernardo, AE Kiszewski, RC Collins, HR Taylor, MA Aziz, and BM Greene

Ivermectin, given to onchocerciasis patients as a single oral dose of 200 micrograms per kilogram of body weight, substantially reduced the uptake of Onchocerca volvulus microfilariae by Simulium yahense, an efficient black fly vector of the parasite in the tropical rain forests of West Africa. Three months after treatment, patients given ivermectin infected flies at a significantly lower rate than those who had received diethylcarbamazine or placebo, thereby reducing the number of developing larvae in the vector population. This diminished rate of infectiousness was also evident 6 months after treatment. These results strongly suggest that ivermectin could be effective in interrupting transmission of Onchocerca volvulus for epidemiologically important periods of time.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
MODELING TARGETED IVERMECTIN TREATMENT FOR CONTROLLING RIVER BLINDNESS.
E. M. POOLMAN and A. P. GALVANI (2006)
Am J Trop Med Hyg 75, 921-927
   Abstract »    Full Text »    PDF »
Impact of mass treatment of onchocerciasis with ivermectin on the transmission of infection.
H. Taylor, M Pacque, B Munoz, and B. Greene (1990)
Science 250, 116-118
   Abstract »    PDF »


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