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Science 14 February 1986:
Vol. 231. no. 4739, pp. 722 - 725
DOI: 10.1126/science.3945805
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Articles
Science, Vol 231, Issue 4739, 722-725
Copyright © 1986 by American Association for the Advancement of Science
Adrenal-mediated endogenous metabolites inhibit puberty in female mice
M Novotny,
B Jemiolo,
S Harvey,
D Wiesler,
and
A Marchlewska-Koj
While assessing a potential role of adrenal glands in the production of the hitherto unidentified puberty-delaying pheromone of female mice, the urinary volatile profiles of normal and adrenalectomized animals were quantitatively compared. Six components, whose concentrations were depressed after adrenalectomy, were identified: 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine. When these laboratory-synthesized chemicals were added (in their natural concentrations) to either previously inactive urine from adrenalectomized females or plain water, the biological activity was fully restored.
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