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Science 7 February 1986:
Vol. 231. no. 4738, pp. 600 - 602
DOI: 10.1126/science.3003906
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Articles

Science, Vol 231, Issue 4738, 600-602
Copyright © 1986 by American Association for the Advancement of Science

articles

Induction of HTLV-III/LAV from a nonvirus-producing T-cell line: implications for latency

T Folks, DM Powell, MM Lightfoote, S Benn, MA Martin, and AS Fauci

When the human T-cell line A3.01 is infected with HTLV-III/LAV, the virus associated with the acquired immune deficiency syndrome (AIDS), most of the cells are killed. However, a small number of cells that lack the Leu-3 surface marker survive. Under normal conditions these surviving cells do not produce virus, nor can they be infected by the virus, but they can be induced to produce virus by treatment with 5-iodo-2'-deoxyuridine. This response can be induced for as long as 3 months after the initial infection, suggesting that the cells may harbor a latent form of HTLV-III/LAV.


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