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Science 24 January 1986:
Vol. 231. no. 4736, pp. 395 - 397
DOI: 10.1126/science.3941902
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Articles

Science, Vol 231, Issue 4736, 395-397
Copyright © 1986 by American Association for the Advancement of Science

articles

A balanced translocation in mice with a neurological defect

JC Rutledge, KT Cain, NL Cacheiro, CV Cornett, CG Wright, and WM Generoso

A semisterile male translocation heterozygote [t(2; 14) 1Gso] that exhibited neurological symptoms and an inability to swim (diver) was found among the offspring of male mice treated with triethylenemelamine. All breeding and cytogenetic data showed a complete concordance between translocation heterozygosity and the neurological disorders. Homozygosity for the translocation seemed to be lethal at an early embryonic stage. Despite the distinctive neurologic symptoms, no anatomic or histological defects in either the ear or in the central nervous system were observed. Thus, a balanced chromosomal translocation can produce disease with an inheritance pattern that mimics a single dominant gene defect.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Germline Translocations in Mice: Unique Tools for Analyzing Gene Function and Long-Distance Regulatory Mechanisms.
C. Elso, X. Lu, S. Morrison, A. Tarver, H. Thompson, H. Thurkow, N.. A. Yamada, and L. Stubbs (2008)
J Natl Cancer Inst Monographs 2008, 91-95
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