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Science 24 January 1986:
Vol. 231. no. 4736, pp. 385 - 388
DOI: 10.1126/science.3001935
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Articles

Science, Vol 231, Issue 4736, 385-388
Copyright © 1986 by American Association for the Advancement of Science

articles

Prostacyclin stimulation of the activation of blood coagulation factor X by platelets

AK Dutta-Roy, TK Ray, and AK Sinha

When platelets were incubated with prostacyclin, prostaglandin E1, or prostaglandin D2 at concentrations insufficient to increase the level of adenosine 3',5'-monophosphate (cyclic AMP), coagulation factor X was activated by a platelet cysteine protease. Prostacyclin or prostaglandin E1 at higher concentrations increased the cyclic AMP level and inhibited the activation of factor X by platelets. Inhibition of platelet adenylate cyclase by 2',5'-dideoxyadenosine allowed the activation of the protease at higher concentrations of the autocoids. Prostaglandins A1, A2, B1, B2, E2, F2 alpha, 6-keto-prostaglandin F1 alpha, and thromboxane B2, which do not affect platelet cyclic AMP level, did not stimulate the protease.


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