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Science 10 January 1986:
Vol. 231. no. 4734, pp. 161 - 163
DOI: 10.1126/science.2867600
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Articles

Science, Vol 231, Issue 4734, 161-163
Copyright © 1986 by American Association for the Advancement of Science

articles

Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus

JR Mancillas, GR Siggins, and FE Bloom

In rat hippocampal pyramidal cells tested in situ by iontophoresis of several neurotransmitters, ethanol significantly enhanced excitatory responses to acetylcholine and inhibitory responses to somatostatin-14 but had no statistically significant effect on excitatory responses to glutamate or inhibitory responses to gamma-aminobutyric acid or, in preliminary tests, to norepinephrine or serotonin. The effects of ethanol on responses to acetylcholine and somatostatin-14 may provide insight into synaptic mechanisms underlying the behavioral consequences of ethanol intoxication.


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