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Science 10 January 1986:
Vol. 231. no. 4734, pp. 153 - 156
DOI: 10.1126/science.3079916
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Articles

Science, Vol 231, Issue 4734, 153-156
Copyright © 1986 by American Association for the Advancement of Science

articles

Rat resistance to schistosomiasis: platelet-mediated cytotoxicity induced by C-reactive protein

D Bout, M Joseph, M Pontet, H Vorng, D Deslee, and A Capron

In rats infected with the parasite Schistosoma mansoni, the concentration of C-reactive protein in the serum increases after the lung stage of infection and is at its highest at the time of terminal worm rejection. The peak of platelet-mediated cytotoxicity induced by infected serum that has been heated (and is free of immunoglobulin E) as well as the time course for the development of platelet cytotoxic activity in infected rats was found to be correlated with the concentration of C-reactive protein. Rat and human platelets treated with homologous serum obtained during an acute phase of inflammation or with purified C-reactive protein were able to kill the immature forms of the worm in vitro. Platelets treated with C-reactive protein were furthermore capable of conferring significant protection against schistosomiasis in transfer experiments. Collectively these data indicate that a system that includes C-reactive protein and platelets participates in the natural resistance of the rat to schistosomal infection.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host.
W. Khovidhunkit, M.-S. Kim, R. A. Memon, J. K. Shigenaga, A. H. Moser, K. R. Feingold, and C. Grunfeld (2004)
J. Lipid Res. 45, 1169-1196
   Abstract »    Full Text »    PDF »
Partial Purification and Immunohistochemical Localization of ATP Diphosphohydrolase from Schistosoma mansoni. IMMUNOLOGICAL CROSS-REACTIVITIES WITH POTATO APYRASE AND TOXOPLASMA GONDII NUCLEOSIDE TRIPHOSPHATE HYDROLASE.
E. G. Vasconcelos, S. T. Ferreira, T. M.U.d. Carvalho, W. d. Souza, A. M. Kettlun, M. Mancilla, M. A. Valenzuela, and S. Verjovski-Almeida (1996)
J. Biol. Chem. 271, 22139-22145
   Abstract »    Full Text »    PDF »


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