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Science 20 December 1985:
Vol. 230. no. 4732, pp. 1381 - 1383
DOI: 10.1126/science.2416057
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Articles

Science, Vol 230, Issue 4732, 1381-1383
Copyright © 1985 by American Association for the Advancement of Science

articles

Sequence of the immunodominant epitope for the surface protein on sporozoites of Plasmodium vivax

TF McCutchan, AA Lal, VF de la Cruz, LH Miller, WL Maloy, Y Charoenvit, RL Beaudoin, P Guerry, R Wistar Jr, SL Hoffman, and al. et

Plasmodium vivax is one of the four malaria parasites that cause disease in humans. The structure of the immunodominant repeating peptide of the circumsporozoite (CS) protein of P. vivax was determined. A fragment of P. vivax DNA that encodes this tandemly repeating epitope was isolated by use of an oligonucleotide probe whose sequence is thought to be conserved in CS protein genes. DNA sequence analysis of the P. vivax clone indicates that the CS repeat is nine amino acids in length (Gly-Asp-Arg-Ala-Asp-Gly-Gln-Pro-Ala). The structure of the repeating region was confirmed with synthetic peptides and monoclonal antibodies directed against P. vivax sporozoites. This information should allow synthesis of a vaccine for P. vivax that is similar to the one being tested for P. falciparum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Studies on the Salvador I Strain of Plasmodium vivax in Non-human Primates and Anopheline Mosquitoes.
W. E. Collins, J. S. Sullivan, E. Strobert, G. G. Galland, A. Williams, D. Nace, T. Williams, and J. W. Barnwell (2009)
Am J Trop Med Hyg 80, 228-235
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A Novel Chimeric Plasmodium vivax Circumsporozoite Protein Induces Biologically Functional Antibodies That Recognize both VK210 and VK247 Sporozoites.
A. Yadava, J. Sattabongkot, M. A. Washington, L. A. Ware, V. Majam, H. Zheng, S. Kumar, and C. F. Ockenhouse (2007)
Infect. Immun. 75, 1177-1185
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Cell Adhesion to a Motif Shared by the Malaria Circumsporozoite Protein and Thrombospondin Is Mediated by Its Glycosaminoglycan-binding Region and Not by CSVTCG.
S. M. Gantt, P. Clavijo, X. Bai, J. D. Esko, and P. Sinnis (1997)
J. Biol. Chem. 272, 19205-19213
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Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence.
Y Charoenvit, W. Collins, T. Jones, P Millet, L Yuan, G. Campbell, R. Beaudoin, Broderson JR, and S. Hoffman (1991)
Science 251, 668-671
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Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax.
R Rosenberg, R. Wirtz, D. Lanar, J Sattabongkot, T Hall, A. Waters, and C Prasittisuk (1989)
Science 245, 973-976
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Research toward malaria vaccines.
L. Miller, R. Howard, R Carter, M. Good, V Nussenzweig, and R. Nussenzweig (1986)
Science 234, 1349-1356
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