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Science 6 December 1985:
Vol. 230. no. 4730, pp. 1168 - 1171
DOI: 10.1126/science.2933808
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Articles

Science, Vol 230, Issue 4730, 1168-1171
Copyright © 1985 by American Association for the Advancement of Science

articles

Biosynthesis and secretion of proatrial natriuretic factor by cultured rat cardiocytes

KD Bloch, JA Scott, JB Zisfein, JT Fallon, MN Margolies, CE Seidman, GR Matsueda, CJ Homcy, RM Graham, and JG Seidman

Rat atrial natriuretic factor (ANF) is translated as a 152-amino acid precursor preproANF. PreproANF is converted to the 126-amino acid proANF, the storage form of ANF in the atria. ANF isolated from the blood is approximately 25 amino acids long. It is demonstrated here that rat cardiocytes in culture store and secrete proANF. Incubation of proANF with serum produced a smaller ANF peptide. PreproANF seems to be processed to proANF in the atria, and proANF appears to be released into the blood, where it is converted by a protease to a smaller peptide.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Role of a Molecular Variant of Rat Atrial Natriuretic Peptide Gene in Vascular Remodeling.
P. De Paolis, V. Nobili, A. Lombardi, D. Tarasi, D. Barbato, S. Marchitti, U. Ganten, E. Brunetti, M. Volpe, and S. Rubattu (2007)
Ann. Clin. Lab. Sci. 37, 135-140
   Abstract »    Full Text »    PDF »
Lack of activation of molecular forms of the BNP system in human grade 1 hypertension and relationship to cardiac hypertrophy.
P. Belluardo, A. Cataliotti, L. Bonaiuto, E. Giuffre, E. Maugeri, P. Noto, G. Orlando, G. Raspa, B. Piazza, L. Babuin, et al. (2006)
Am J Physiol Heart Circ Physiol 291, H1529-H1535
   Abstract »    Full Text »    PDF »
Atrial natriuretic peptides in pathophysiological diseases.
D. L Vesely (2001)
Cardiovasc Res 51, 647-658
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The Natriuretic Peptides: Physiology and Role in Left-Ventricular Dysfunction.
S. D. Kim and M. R. Piano (2000)
Biol Res Nurs 2, 15-29
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Altered Structure, Regulation, and Function of the Gene Encoding the Atrial Natriuretic Peptide in the Stroke-Prone Spontaneously Hypertensive Rat.
S. Rubattu, M. A. Lee-Kirsch, P. DePaolis, R. Giliberti, B. Gigante, A. Lombardi, M. Volpe, and K. Lindpaintner (1999)
Circ. Res. 85, 900-905
   Abstract »    Full Text »    PDF »
Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.
W. Yan, F. Wu, J. Morser, and Q. Wu (2000)
PNAS 97, 8525-8529
   Abstract »    Full Text »    PDF »


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