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Science 22 November 1985:
Vol. 230. no. 4728, pp. 940 - 942
DOI: 10.1126/science.3840606
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Articles

Science, Vol 230, Issue 4728, 940-942
Copyright © 1985 by American Association for the Advancement of Science

articles

Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders

HF Willard and Riordan JR

Several inherited disorders in humans and in rodents result in myelin dysgenesis and a deficiency of the molecular constituents of myelin. A complementary DNA to one of the two major myelin proteins, myelin proteolipid protein (also known as lipophilin), has been used with Southern blot analysis of somatic cell hybrid DNA to map the human proteolipid protein gene to the middle of the long arm of the human X chromosome (bands Xq13-Xq22) and to assign the murine proteolipid protein gene to the mouse X chromosome. Comparison of the gene maps of the human and mouse X chromosomes suggests that myelin proteolipid protein may be involved in X-linked mutations at the mouse jimpy locus and has implications for Pelizaeus-Merzbacher disease, a human inherited X-linked myelin disorder.


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Separate Proteolipid Protein/DM20 Enhancers Serve Different Lineages and Stages of Development.
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Expression of the inhibitor of apoptosis protein family in multiple sclerosis reveals a potential immunomodulatory role during autoimmune mediated demyelination.
A. Hebb, C. Moore, V Bhan, T Campbell, J. Fisk, H. Robertson, M Thorne, E Lacasse, M Holcik, J Gillard, et al. (2008)
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Gap junction protein 12: "Connexing" the pieces in the puzzle of myelination and leukodystrophy.
S. Mar and M. J. Noetzel (2008)
Neurology 70, 744-745
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Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease.
J. A. Lee, K. Inoue, S. W. Cheung, C. A. Shaw, P. Stankiewicz, and J. R. Lupski (2006)
Hum. Mol. Genet. 15, 2250-2265
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Census of Genes Expressed in Porcine Embryos and Reproductive Tissues by Mining an Expressed Sequence Tag Database Based on Human Genes.
Z. Jiang, M. Zhang, V. D. Wasem, J. J. Michal, H. Zhang, and R. W. Wright Jr (2003)
Biol Reprod 69, 1177-1182
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The proteolipid protein gene and myelin disorders in man and animal models.
D. A. Yool, J. M. Edgar, P. Montague, and S. Malcolm (2000)
Hum. Mol. Genet. 9, 987-992
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Visual Evoked Potential Characteristics and Early Diagnosis of Pelizaeus-Merzbacher Disease.
P. Apkarian, J. C. Koetsveld-Baart, and P. G. Barth (1993)
Arch Neurol 50, 981-985
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Cloning of human androgen receptor complementary DNA and localization to the X chromosome.
D. Lubahn, D. Joseph, P. Sullivan, H. Willard, F. French, and E. Wilson (1988)
Science 240, 327-330
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Human ribosomal RNA genes: orientation of the tandem array and conservation of the 5' end.
R. Worton, J Sutherland, J. Sylvester, H. Willard, S Bodrug, I Dube, C Duff, V Kean, P. Ray, and R. Schmickel (1988)
Science 239, 64-68
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Molecular genetics: applications to the clinical neurosciences.
J. Martin (1987)
Science 238, 765-772
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Familial Spastic Paraparesis and Deafness: A New X-linked Neurodegenerative Disorder.
C. R. Wells and J. Jankovic (1986)
Arch Neurol 43, 943-946
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Mapping of the Cystic Fibrosis Locus on Chromosome 7.
L.-C. Tsui, S. Zengerling, H.F. Willard, and M. Buchwald (1986)
Cold Spring Harb Symp Quant Biol 51, 325-335
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