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Science 15 November 1985:
Vol. 230. no. 4727, pp. 810 - 813
DOI: 10.1126/science.2997921
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Articles

Science, Vol 230, Issue 4727, 810-813
Copyright © 1985 by American Association for the Advancement of Science

articles

A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients

JS Allan, JE Coligan, TH Lee, MF McLane, PJ Kanki, JE Groopman, and M Essex

A newly identified protein from HTLV-III/LAV, the virus implicated as the etiologic agent of the acquired immune deficiency syndrome, was studied. This protein, which has a molecular weight of 27,000 (p27), was shown by amino acid sequencing to have a coding origin 3' to the env gene on the HTLV-III genome. The presence of antibodies to p27 in virus-exposed individuals indicated that this gene is functional in the natural host.


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