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Science 15 November 1985:
Vol. 230. no. 4727, pp. 808 - 810
DOI: 10.1126/science.4059913
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Articles

Science, Vol 230, Issue 4727, 808-810
Copyright © 1985 by American Association for the Advancement of Science

articles

Hypertension in the recently weaned Dahl salt-sensitive rat despite a diet deficient in sodium chloride

TW Kurtz and RC Morris Jr

The Dahl rat is used as a model of hypertension that is "sensitive" to dietary salt (sodium chloride, NaCl). When dietary salt is supplemented in the Dahl rat, the arterial blood pressure of the "salt-sensitive" strain (S) becomes much greater than that of the "salt-resistant" strain (R). It has been widely reported that arterial blood pressure of the young Dahl S rat is not greater than that of the young Dahl R rat before dietary salt is supplemented. In the present study, however, mean arterial pressure directly measured in unanesthetized, unrestrained S rats was greater than in R rats, both when they had been recently weaned and for at least 10 weeks thereafter, despite their having been fed a diet frankly deficient in salt. In weanling S rats, the ratio of heart weight to body weight was also significantly greater than that in weanling R rats, suggesting that the greater blood pressure in the S rat causes cardiac hypertrophy. Thus, biologic differences demonstrated between the S rat and the R rat after weaning, including the phenomenon of salt-sensitivity, could be a consequence of, or be dependent on, an already extant difference in arterial blood pressure between the two strains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Gene Expression Profiling in Hypertension Research: A Critical Perspective.
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Plasma and Renal Prorenin/Renin, Renin mRNA, and Blood Pressure in Dahl Salt-Sensitive and Salt-Resistant Rats.
W. G. Campbell Jr, F. Gahnem, D. F. Catanzaro, G. D. James, M. J. F. Camargo, J. H. Laragh, and J. E. Sealey (1996)
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