Science, Vol 230, Issue 4725, 558-561
Copyright © 1985 by American Association for the Advancement of Science
Coronary vasoconstrictor effects of atriopeptin II
RD Wangler,
BA Breuhaus,
HO Otero,
DA Hastings,
MD Holzman,
HH Saneii,
HV Sparks Jr,
and
JE Chimoskey
Atrial natriuretic peptides lower arterial pressure, cardiac filling pressure, and cardiac output. In isolated, Langendorff-perfused guinea pig hearts, atriopeptin II, the 23-amino acid atrial natriuretic peptide, is also a potent coronary vasoconstrictor. The median effective dose for atriopeptin II in guinea pig hearts is 26 nanomoles, the threshold constrictor dose is 5 nanomoles, and flow nearly ceases at a dose of 100 nanomoles in perfused hearts at constant pressure. Similar concentrations of atriopeptin II also cause coronary vasoconstriction in rat and dog heart preparations. The disulfide bridge is necessary for vasoconstrictor activity; reduction of this bridge abolishes the activity, as it does the other biological activities of atrial natriuretic peptides.
