Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 November 1985:
Vol. 230. no. 4725, pp. 543 - 545
DOI: 10.1126/science.4048947
Prev | Table of Contents | Next

Articles

Science, Vol 230, Issue 4725, 543-545
Copyright © 1985 by American Association for the Advancement of Science

articles

Enzymatic removal of bilirubin from blood: a potential treatment for neonatal jaundice

A Lavin, C Sung, AM Klibanov, and R Langer

Current treatments for severe jaundice can result in major complications. Neonatal jaundice is caused by excessive accumulation of bilirubin in the blood. A small blood filter containing immobilized bilirubin oxidase was developed to reduce serum bilirubin concentrations. When human or rat blood was passed through the enzyme filter, more than 90 percent of the bilirubin was degraded in a single pass. This procedure may have important applications in the clinical treatment of neonatal jaundice.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neonatal Hyperbilirubinemia.
P. A. Dennery, D. S. Seidman, and D. K. Stevenson (2001)
N. Engl. J. Med. 344, 581-590
   Full Text »    PDF »
Arginase Immobilization on Poly(hydroxyethyl acrylate) Matrix Beads.
F.M. Veronese, E. Boccu, P. Caliceti, S. Lora, M. Carenza, and G. Palma (1989)
Journal of Bioactive and Compatible Polymers 4, 42-50
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)