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Science 1 November 1985:
Vol. 230. no. 4725, pp. 511 - 517
DOI: 10.1126/science.2996137
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Articles

Science, Vol 230, Issue 4725, 511-517
Copyright © 1985 by American Association for the Advancement of Science

articles

Bidirectional SV40 transcription mediated by tandem Sp1 binding interactions

D Gidoni, JT Kadonaga, H Barrera-Saldana, K Takahashi, P Chambon, and R Tjian

The 21-base pair repeat elements of the SV40 promoter contain six tandem copies of the GGGCGG hexanucleotide (GC-box), each of which can bind, with varying affinity, to the cellular transcription factor, Sp1. In vitro SV40 early RNA synthesis is mediated by interaction of Sp1 with GC-boxes I, II, and III, whereas transcription in the late direction is mediated by binding to GC-boxes III, V, and VI.


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