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Science 11 October 1985:
Vol. 230. no. 4722, pp. 181 - 183
DOI: 10.1126/science.3875898
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Articles

Science, Vol 230, Issue 4722, 181-183
Copyright © 1985 by American Association for the Advancement of Science

articles

Distinct monoamine oxidase A and B populations in primate brain

KN Westlund, RM Denney, LM Kochersperger, RM Rose, and CW Abell

Monoclonal antibodies specific for monoamine oxidase (MAO) A and MAO B, respectively, were used to localize these enzymes in primate brain. The reagents recognized different populations of neurons: those that recognized MAO A were located in cell groups containing catecholamines, including the substantia nigra, nucleus locus coeruleus, nucleus subcoeruleus, and the periventricular region of the hypothalamus, whereas those that recognized MAO B were observed in serotonin regions, including the nucleus raphe dorsalis and nucleus centralis superior. These data illustrate the physiological independence of MAO A and B and show that neurons may be specialized for their degradative as well as their synthetic functions.


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