Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 October 1985:
Vol. 230. no. 4721, pp. 89 - 90
DOI: 10.1126/science.3898368
Prev | Table of Contents

Articles

Science, Vol 230, Issue 4721, 89-90
Copyright © 1985 by American Association for the Advancement of Science

articles

A neuroendocrine marker in tissues of the immune system

RH Angeletti and WF Hickey

Antibodies to chromogranin, a secretory protein marker for the diffuse neuroendocrine system, were used to analyze rat lymphoreticular tissues by means of immunochemistry and immunohistochemistry. Chromogranin-positive cells were present in spleen, lymph node, thymus, and fetal liver. When these organs were gently dispersed and separated on a Ficoll gradient, the chromogranin-immunoreactive cells became enriched in the dense red-cell pellets. The unexpected distribution of these neuroendocrine cells in all immunologically relevant structures suggests that they may link the nervous and immunological systems.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chromogranin A Fragments Modulate Cell Adhesion. IDENTIFICATION AND CHARACTERIZATION OF A PRO-ADHESIVE DOMAIN.
A. Gasparri, A. Sidoli, L. P. Sanchez, R. Longhi, A. G. Siccardi, P. C. Marchisio, and A. Corti (1997)
J. Biol. Chem. 272, 20835-20843
   Abstract »    Full Text »    PDF »
Chromogranin A as Serum Marker for Neuroendocrine Neoplasia: Comparison with Neuron-Specific Enolase and the {alpha}-Subunit of Glycoprotein Hormones.
F. R. E. Nobels, D. J. Kwekkeboom, W. Coopmans, C. H. H. Schoenmakers, J. Lindemans, W. W. De Herder, E. P. Krenning, R. Bouillon, and S. W. J. Lamberts (1997)
J. Clin. Endocrinol. Metab. 82, 2622-2628
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)