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Science 27 September 1985:
Vol. 229. no. 4720, pp. 1358 - 1365
DOI: 10.1126/science.2994218
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Articles

Science, Vol 229, Issue 4720, 1358-1365
Copyright © 1985 by American Association for the Advancement of Science

articles

Three-dimensional structure of poliovirus at 2.9 A resolution

JM Hogle, M Chow, and DJ Filman

The three-dimensional structure of poliovirus has been determined at 2.9 A resolution by x-ray crystallographic methods. Each of the three major capsid proteins (VP1, VP2, and VP3) contains a "core" consisting of an eight-stranded antiparallel beta barrel with two flanking helices. The arrangement of beta strands and helices is structurally similar and topologically identical to the folding pattern of the capsid proteins of several icosahedral plant viruses. In each of the major capsid proteins, the "connecting loops" and NH2- and COOH-terminal extensions are structurally dissimilar. The packing of the subunit "cores" to form the virion shell is reminiscent of the packing in the T = 3 plant viruses, but is significantly different in detail. Differences in the orientations of the subunits cause dissimilar contacts at protein-protein interfaces, and are also responsible for two major surface features of the poliovirion: prominent peaks at the fivefold and threefold axes of the particle. The positions and interactions of the NH2- and COOH-terminal strands of the capsid proteins have important implications for virion assembly. Several of the "connecting loops" and COOH-terminal strands form prominent radial projections which are the antigenic sites of the virion.


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   Abstract »    PDF »
A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles.
F Delpeyroux, N Chenciner, A Lim, Y Malpiece, B Blondel, R Crainic, S van der Werf, and R. Streeck (1986)
Science 233, 472-475
   Abstract »    PDF »
Three-dimensional structure of the adenovirus major coat protein hexon.
M. Roberts, J. White, M. Grutter, and R. Burnett (1986)
Science 232, 1148-1151
   Abstract »    PDF »
Two Distinct Binding Affinities of Poliovirus for Its Cellular Receptor.
B. M. McDermott Jr., A. H. Rux, R. J. Eisenberg, G. H. Cohen, and V. R. Racaniello (2000)
J. Biol. Chem. 275, 23089-23096
   Abstract »    Full Text »    PDF »
Virus Maturation Targets the Protein Capsid to Concerted Disassembly and Unfolding.
A. C. Oliveira, A. M. O. Gomes, F. C. L. Almeida, R. Mohana-Borges, A. P. Valente, V. S. Reddy, J. E. Johnson, and J. L. Silva (2000)
J. Biol. Chem. 275, 16037-16043
   Abstract »    Full Text »    PDF »
Supramolecular Chemistry And Self-assembly Special Feature: Organization of the interior of molecular capsules by hydrogen bonding.
J. L. Atwood, L. J. Barbour, and A. Jerga (2002)
PNAS 99, 4837-4841
   Abstract »    Full Text »    PDF »


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