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Science 6 September 1985:
Vol. 229. no. 4717, pp. 989 - 991
DOI: 10.1126/science.2992093
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Articles

Science, Vol 229, Issue 4717, 989-991
Copyright © 1985 by American Association for the Advancement of Science

articles

Gonadotropin-releasing hormone binding sites in human breast carcinoma

KA Eidne, CA Flanagan, and RP Millar

Gonadotropin-releasing hormone analogs can cause regression of hormone-dependent breast carcinomas. These effects are thought to be mediated through the inhibition of gonadotropic and steroid hormones. These analogs may also act directly on the tumor because they are effective in treating breast cancer in some postmenopausal women. The presence of specific binding sites for gonadotropin-releasing hormone was demonstrated in human breast carcinomas by means of a novel approach of ligand immunoblotting. The results indicate a possible mechanism by which the peptide has direct effects on this tissue. These binding proteins were not detectable in non-neoplastic breast tissue.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Gonadotropin-Releasing Hormone Receptor Levels and Cell Context Affect Tumor Cell Responses to Agonist In vitro and In vivo.
K. Morgan, A. J. Stewart, N. Miller, P. Mullen, M. Muir, M. Dodds, F. Medda, D. Harrison, S. Langdon, and R. P. Millar (2008)
Cancer Res. 68, 6331-6340
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Gonadotropin-Releasing Hormone Analog Structural Determinants of Selectivity for Inhibition of Cell Growth: Support for the Concept of Ligand-Induced Selective Signaling.
R. Lopez de Maturana, A. J. Pawson, Z.-L. Lu, L. Davidson, S. Maudsley, K. Morgan, S. P. Langdon, and R. P. Millar (2008)
Mol. Endocrinol. 22, 1711-1722
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Targeting of Cytotoxic Luteinizing Hormone-Releasing Hormone Analogs to Breast, Ovarian, Endometrial, and Prostate Cancers.
A. Nagy and A. V. Schally (2005)
Biol Reprod 73, 851-859
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Molecular Biology of Gonadotropin-Releasing Hormone (GnRH)-I, GnRH-II, and Their Receptors in Humans.
C. K. Cheng and P. C. K. Leung (2005)
Endocr. Rev. 26, 283-306
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Gonadotropin-Releasing Hormone (GnRH) Antagonists Promote Proapoptotic Signaling in Peripheral Reproductive Tumor Cells by Activating a G{alpha}i-Coupling State of the Type I GnRH Receptor.
S. Maudsley, L. Davidson, A. J. Pawson, R. Chan, R. L. de Maturana, and R. P. Millar (2004)
Cancer Res. 64, 7533-7544
   Abstract »    Full Text »    PDF »
Outside-In and Inside-Out Signaling: The New Concept that Selectivity of Ligand Binding at the Gonadotropin-Releasing Hormone Receptor Is Modulated by the Intracellular Environment.
R. P. Millar and A. J. Pawson (2004)
Endocrinology 145, 3590-3593
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Gonadotropin-Releasing Hormone Receptor-Mediated Growth Suppression of Immortalized L{beta}T2 Gonadotrope and Stable HEK293 Cell Lines.
L. E. C. Miles, A. C. Hanyaloglu, J. R. Dromey, K. D. G. Pfleger, and K. A. Eidne (2004)
Endocrinology 145, 194-204
   Abstract »    Full Text »    PDF »
Peptide Receptors as Molecular Targets for Cancer Diagnosis and Therapy.
J. C. Reubi (2003)
Endocr. Rev. 24, 389-427
   Abstract »    Full Text »    PDF »
Type II Gonadotropin-Releasing Hormone Receptor Transcripts in Human Sperm.
W. van Biljon, S. Wykes, S. Scherer, S.A. Krawetz, and J. Hapgood (2002)
Biol Reprod 67, 1741-1749
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Expression of GnRH receptor in mouse and rat testicular germ cells.
P. Bull, P. Morales, C. Huyser, T. Socias, and E.A. Castellon (2000)
Mol. Hum. Reprod. 6, 582-586
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Vaccination against Gonadotropin-releasing Hormone (GnRH) Using Toxin Receptor-binding Domain-conjugated GnRH Repeats.
C.-T. Hsu, C.-Y. Ting, C.-J. Ting, T.-Y. Chen, C.-P. Lin, J. Whang-Peng, and J. Hwang (2000)
Cancer Res. 60, 3701-3705
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Role of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Cascade in Gonadotropin-releasing Hormone-induced Growth Inhibition of a Human Ovarian Cancer Cell Line.
A. Kimura, M. Ohmichi, H. Kurachi, H. Ikegami, J. Hayakawa, K. Tasaka, Y. Kanda, Y. Nishio, H. Jikihara, N. Matsuura, et al. (1999)
Cancer Res. 59, 5133-5142
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