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Science 23 August 1985:
Vol. 229. no. 4715, pp. 779 - 782
DOI: 10.1126/science.4023712
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Articles

Science, Vol 229, Issue 4715, 779-782
Copyright © 1985 by American Association for the Advancement of Science

articles

Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi

S Sharma, P Svec, GH Mitchell, and GN Godson

The complete nucleotide sequence of the coding region of the circumsporozoite antigen gene (CS gene) of the Nuri strain of the malarial parasite Plasmodium knowlesi is presented. The gene from the Nuri strain exhibits a novel form of sequence diversity when compared to the CS gene from the H strain. Instead of the 12 tandem repeating 36-base pair units of the H strain, the Nuri strain contains 16 tandem repeating 27-base pair units of a different nucleotide sequence that encodes a different repeating peptide. In contrast, the 5' and 3' coding and noncoding sequences flanking the repeats are 98 percent conserved in both strains.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transfection of the Primate Malaria Parasite Plasmodium knowlesi Using Entirely Heterologous Constructs.
A. M. v. d. Wel, A. M. Tomas, C. H.M. Kocken, P. Malhotra, C. J. Janse, A. P. Waters, and A. W. Thomas (1997)
J. Exp. Med. 185, 1499-1504
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Circumsporozoite protein heterogeneity in the human malaria parasite Plasmodium vivax.
R Rosenberg, R. Wirtz, D. Lanar, J Sattabongkot, T Hall, A. Waters, and C Prasittisuk (1989)
Science 245, 973-976
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Research toward malaria vaccines.
L. Miller, R. Howard, R Carter, M. Good, V Nussenzweig, and R. Nussenzweig (1986)
Science 234, 1349-1356
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Sequence of the immunodominant epitope for the surface protein on sporozoites of Plasmodium vivax.
T. McCutchan, A. Lal, V. de la Cruz, L. Miller, W. Maloy, Y Charoenvit, R. Beaudoin, P Guerry, R Wistar Jr, S. Hoffman, et al. (1985)
Science 230, 1381-1383
   Abstract »    PDF »
Circumsporozoite protein of Plasmodium vivax: gene cloning and characterization of the immunodominant epitope.
D. Arnot, J. Barnwell, J. Tam, V Nussenzweig, R. Nussenzweig, and V Enea (1985)
Science 230, 815-818
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