Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 23 August 1985:
Vol. 229. no. 4715, pp. 776 - 779
DOI: 10.1126/science.2992086
Prev | Table of Contents | Next

Articles

Science, Vol 229, Issue 4715, 776-779
Copyright © 1985 by American Association for the Advancement of Science

articles

Huntington's disease: two families with differing clinical features show linkage to the G8 probe

SE Folstein, JA Phillips 3rd, DA Meyers, GA Chase, MH Abbott, ML Franz, PG Waber, HH Kazazian Jr, PM Conneally, W Hobbs, and al. et

To test the hypothesis that interfamily variability in Huntington's Disease (HD) is due to mutation at different loci, linkage analysis was undertaken in two large HD kindreds that differed in ethnicity, age-at-onset, and neurologic and psychiatric features. Both families showed linkage of the HD locus to the G8 probe. Several recombinants were documented in each family, and the best estimate of the recombination fraction for the two families was 6 percent with a 95 percent confidence interval of 0 to 12 percent. Although the data support the existence of a single HD locus, use of the G8 probe for presymptomatic testing in these kindreds would have resulted in a 12 percent error rate in genotype assignment at the HD locus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Psychiatric, Genetic, and Positron Emission Tomographic Evaluation of Persons at Risk for Huntington's Disease.
L. R. Baxter Jr, J. C. Mazziotta, J. J. Pahl, S. T. Grafton, P. St. George-Hyslop, J. L. Haines, J. F. Gusella, M. P. Szuba, C. E. Selin, B. H. Guze, et al. (1992)
Arch Gen Psychiatry 49, 148-154
   Abstract »    PDF »
Site-specific cleavage of human chromosome 4 mediated by triple-helix formation.
S. Strobel, L. Doucette-Stamm, L Riba, D. Housman, and P. Dervan (1991)
Science 254, 1639-1642
   Abstract »    PDF »
Presymptomatic Diagnosis of Delayed-Onset Disease With Linked DNA Markers: The Experience in Huntington's Disease.
J. Brandt, K. A. Quaid, S. E. Folstein, P. Garber, N. E. Maestri, M. H. Abbott, P. R. Slavney, M. L. Franz, L. Kasch, and H. H. Kazazian Jr (1989)
JAMA 261, 3108-3114
   Abstract »    PDF »
The Molecular Genetic Revolution: Its Impact on Clinical Neurology.
C. S. Payne and A. D. Roses (1988)
Arch Neurol 45, 1366-1376
   Abstract »    PDF »
Molecular genetics: applications to the clinical neurosciences.
J. Martin (1987)
Science 238, 765-772
   Abstract »    PDF »
Big Genes, Little Genes, Affective Disorder, and Anxiety: A Commentary.
G. Carey (1987)
Arch Gen Psychiatry 44, 486-491
   Abstract »    PDF »
Cerebral Cation Shifts and Amino Acids in Huntington's Disease.
J. B. Gramsbergen, L. Veenma-Van der Duin, K. Venema, and J. Korf (1986)
Arch Neurol 43, 1276-1281
   Abstract »    PDF »
Molecular Genetics of Huntington's Disease.
J.F. Gusella, T.C. Gilliam, R.E. Tanzi, M.E. MacDonald, S.V. Cheng, M. Wallace, J. Haines, P.M. Conneally, and N.S. Wexler (1986)
Cold Spring Harb Symp Quant Biol 51, 359-364
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)