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Science 9 August 1985:
Vol. 229. no. 4713, pp. 558 - 561
DOI: 10.1126/science.2992080
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Articles

Science, Vol 229, Issue 4713, 558-561
Copyright © 1985 by American Association for the Advancement of Science

articles

Effects of genomic position on the expression of transduced copies of the white gene of Drosophila

R Levis, T Hazelrigg, and GM Rubin

The white gene of Drosophila is expressed normally when introduced at many different sites in the genome by P-element-mediated DNA transformation, but is expressed abnormally when inserted at two particular genomic positions. It is now demonstrated that the mutant expression in these two cases is caused by the surrounding chromosomal region into which the white gene has been inserted. The white gene could be moved from these two positions, where it confers a mutant phenotype, to other positions in the genome where it confers a wild-type phenotype. However, flies in which white has been moved to one new location have an unusual mosaic phenotype.


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