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Science 2 August 1985:
Vol. 229. no. 4712, pp. 482 - 485
DOI: 10.1126/science.2990051
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Articles

Science, Vol 229, Issue 4712, 482-485
Copyright © 1985 by American Association for the Advancement of Science

articles

cis- and trans-acting transcriptional regulation of visna virus

JL Hess, JE Clements, and O Narayan

Visna virus is a pathogenic lentivirus of sheep that is related to human T-cell lymphotropic virus type III (HTLV-III), the probable etiologic agent of the acquired immune deficiency syndrome (AIDS). The transcriptional activity of visna virus promoter and enhancer sequences was studied by means of an assay based on the transient expression of the bacterial gene chloramphenicol acetyltransferase (CAT). The results suggest that the high level of expression of visna virus is due in part to cis-acting enhancer sequences that give the viral promoter a high level of transcriptional activity. In addition, the rate of transcription from the visna virus promoter situated in a plasmid expressing the CAT gene was much greater in infected than uninfected cells. This phenomenon of trans-acting transcriptional activation may involve either virally or cellularly encoded factors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Duplicated Sequence Motif in the Long Terminal Repeat of Maedi-Visna Virus Extends Cell Tropism and Is Associated with Neurovirulence.
T. Oskarsson, H. S. Hreggvidsdottir, G. Agnarsdottir, S. Matthiasdottir, M. H. Ogmundsdottir, S. R. Jonsson, G. Georgsson, S. Ingvarsson, O. S. Andresson, and V. Andresdottir (2007)
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Feline Immunodeficiency Virus OrfA Is Distinct from Other Lentivirus Transactivators.
U. Chatterji, A. de Parseval, and J. H. Elder (2002)
J. Virol. 76, 9624-9634
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Binding of Tat to TAR and Recruitment of Positive Transcription Elongation Factor b Occur Independently in Bovine Immunodeficiency Virus.
M. Barboric, R. Taube, N. Nekrep, K. Fujinaga, and B. M. Peterlin (2000)
J. Virol. 74, 6039-6044
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