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Science 19 July 1985:
Vol. 229. no. 4710, pp. 284 - 287
DOI: 10.1126/science.2861660
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Articles

Science, Vol 229, Issue 4710, 284-287
Copyright © 1985 by American Association for the Advancement of Science

articles

Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor

WC Mobley, JL Rutkowski, GI Tennekoon, K Buchanan, and MV Johnston

Some neurodegenerative disorders may be caused by abnormal synthesis or utilization of trophic molecules required to support neuronal survival. A test of this hypothesis requires that trophic agents specific for the affected neurons be identified. Cholinergic neurons in the corpus striatum of neonatal rats were found to respond to intracerebroventricular administration of nerve growth factor with prominent, dose-dependent, selective increases in choline acetyltransferase activity. Cholinergic neurons in the basal forebrain also respond to nerve growth factor in this way. These actions of nerve growth factor may indicate its involvement in the normal function of forebrain cholinergic neurons as well as in neurodegenerative disorders involving such cells.


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