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Science 5 July 1985:
Vol. 229. no. 4708, pp. 67 - 69
DOI: 10.1126/science.3925552
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Articles

Science, Vol 229, Issue 4708, 67-69
Copyright © 1985 by American Association for the Advancement of Science

articles

Thyrotropin-releasing hormone induces rhythmic bursting in neurons of the nucleus tractus solitarius

MS Dekin, GB Richerson, and PA Getting

The nucleus tractus solitarius (NTS) contains neurons that are part of the central neuronal network controlling rhythmic breathing movements in mammals. Nerve terminals within the NTS show immunoreactivity to thyrotropin-releasing hormone (TRH), a neuropeptide that has potent stimulatory effects on respiration. By means of a brainstem slice preparation in vitro, TRH induced rhythmic bursting in neurons in the respiratory division of the NTS. The frequency of bursting was voltage-dependent and could be reset by short depolarizing current pulses. In the presence of tetrodotoxin, TRH produced rhythmic oscillations in membrane potential whose frequency was also voltage-dependent. These observations suggest that TRH modulates the membrane excitability of NTS neurons and allows them to express endogenous bursting activity.


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Acidosis-Stimulated Neurons of the Medullary Raphe Are Serotonergic.
W. Wang, J. K. Tiwari, S. R. Bradley, R. V. Zaykin, and G. B. Richerson (2001)
J Neurophysiol 85, 2224-2235
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Respiratory responses to thyrotropin-releasing hormone microinjected into the rabbit medulla oblongata.
D. Mutolo, F. Bongianni, M. Carfi, and T. Pantaleo (1999)
Am J Physiol Regulatory Integrative Comp Physiol 277, R1331-R1338
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The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides.
E. A. Nillni and K. A. Sevarino (1999)
Endocr. Rev. 20, 599-648
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RTN TRH causes prolonged respiratory stimulation.
C. L. Cream, A. Li, and E. E. Nattie (1997)
J Appl Physiol 83, 792-799
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