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Science 28 June 1985:
Vol. 228. no. 4707, pp. 1540 - 1543
DOI: 10.1126/science.2409597
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Articles

Science, Vol 228, Issue 4707, 1540-1543
Copyright © 1985 by American Association for the Advancement of Science

articles

Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones

J Ritz, TJ Campen, RE Schmidt, HD Royer, T Hercend, RE Hussey, and EL Reinherz

A series of clones of human natural killer (NK) cells was characterized with respect to expression of the Ti alpha and Ti beta genes of the T-cell receptor. T11+T3+ NK clones contained Ti alpha and Ti beta RNA transcripts and expressed disulfide-linked heterodimers, demonstrating the presence of a functional T-cell receptor. In contrast, T11+T3- NK clones expressed only 1.0-kilobase truncated Ti beta transcripts, without a Ti alpha transcript and no detectable surface Ti protein. Since previous studies demonstrated that Ti beta gene activation precedes Ti alpha gene activation in thymic ontogeny, the T11+T3- NK cells appear to be derived from T-lineage precursors.


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