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Science 7 June 1985:
Vol. 228. no. 4704, pp. 1215 - 1217
DOI: 10.1126/science.2988127
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Articles

Science, Vol 228, Issue 4704, 1215-1217
Copyright © 1985 by American Association for the Advancement of Science

articles

Deregulation of interleukin-2 receptor gene expression in HTLV-I-induced adult T-cell leukemia

M Kronke, WJ Leonard, JM Depper, and WC Greene

Infection of human T cells by human T-lymphotropic virus, type I (HTLV-I), a retrovirus, is uniformly associated with the constitutive expression of large numbers of cellular receptors for interleukin-2 (IL-2). Comparison with normal T cells shows that neither IL-2 receptor gene organization nor IL-2 receptor messenger RNA processing are altered in the leukemic cells. However, mitogenic stimuli activate IL-2 receptor gene expression in normal T cells, whereas these stimuli paradoxically inhibit IL-2 receptor gene transcription in HTLV-I-infected leukemic T cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene.
D. Ballard, E Bohnlein, J. Lowenthal, Y Wano, B. Franza, and W. Greene (1988)
Science 241, 1652-1655
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Elevated Serum Levels of Soluble Tac Peptide in Adult T-Cell Leukemia: Correlation with Clinical Status during Chemotherapy.
L. Marcon, L. A. Rubin, C. C. Kurman, M. E. Fritz, D. L. Longo, T. Uchiyama, B. K. Edwards, and D. L. Nelson (1988)
Ann Intern Med 109, 274-279
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The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses.
W. C. GREENE, W. J. LEONARD, J. M. DEPPER, D. L. NELSON, and T. A. WALDMANN (1986)
Ann Intern Med 105, 560-572
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Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
W. Greene, W. Leonard, Y Wano, P. Svetlik, N. Peffer, J. Sodroski, C. Rosen, W. Goh, and W. Haseltine (1986)
Science 232, 877-880
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The Human Interleukin-2 Receptor: Role in Normal T-cell Growth and Association with HTLV-I-induced T-cell Leukemia.
W.C. Greene, J.M. Depper, M. Kronke, and W.J. Leonard (1986)
Cold Spring Harb Symp Quant Biol 51, 731-737
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Structure of the human interleukin-2 receptor gene.
W. Leonard, J. Depper, M Kanehisa, M Kronke, N. Peffer, P. Svetlik, M Sullivan, and W. Greene (1985)
Science 230, 633-639
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