Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 June 1985:
Vol. 228. no. 4704, pp. 1169 - 1175
DOI: 10.1126/science.4001935
Prev | Table of Contents | Next

Articles

Science, Vol 228, Issue 4704, 1169-1175
Copyright © 1985 by American Association for the Advancement of Science

articles

Evolution in inbred strains of mice appears rapid

WM Fitch and WR Atchley

Genetic variation at 97 loci in ten commonly used inbred strains of mice is greatly in excess of that expected under current assumptions. Evidence against all of the readily apparent explanations is presented and the possibility of early selection for heterozygosity or of conversion is suggested. The common ancestor of these strains is estimated to have occurred about 150 years ago.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Outbred CD-1 mice carry the susceptibility allele at the pulmonary adenoma susceptibility 1 (Pas1) locus.
G. Manenti, F. Galbiati, S. Noci, and T. A. Dragani (2003)
Carcinogenesis 24, 1143-1148
   Abstract »    Full Text »    PDF »
Genetic Background Affects Susceptibility to Mammary Hyperplasias and Carcinomas in ApcMin/+ Mice.
A. R. Moser, L. F. Hegge, and R. D. Cardiff (2001)
Cancer Res. 61, 3480-3485
   Abstract »    Full Text »
Spatially Restricted Hypopigmentation Associated with an Ednrbs-Modifying Locus on Mouse Chromosome 10.
H. Rhim, K. J. Dunn, A. Aronzon, S. Mac, M. Cheng, M. L. Lamoreux, S. M. Tilghman, and W. J. Pavan (2000)
Genome Res. 10, 17-29
   Abstract »    Full Text »
Linkage Disequilibrium and Physical Mapping of Pas1 in Mice.
G. Manenti, A. Stafford, L. De Gregorio, M. Gariboldi, F. S. Falvella, P. Avner, and T. A. Dragani (1999)
Genome Res. 9, 639-646
   Abstract »    Full Text »
Phylogenetics of the laboratory rat Rattus norvegicus..
F Canzian (1997)
Genome Res. 7, 262-267
   Abstract »    PDF »
Experimental phylogenetics: generation of a known phylogeny.
D. Hillis, J. Bull, M. White, M. Badgett, and I. Molineux (1992)
Science 255, 589-592
   Abstract »    PDF »
Of genes and genomes.
D. Hillis and J. Bull (1991)
Science 254, 528
   PDF »
Gene trees and the origins of inbred strains of mice.
W. Atchley and W. Fitch (1991)
Science 254, 554-558
   Abstract »    PDF »
Rapid mutations in mice?.
F.M JOHNSON, C.F AQUADRO, L.C SKOW, and C.H LANGLEY (1985)
Science 230, 1406-1409
   PDF »
Rapid Mutations in Mice?.
M. C. GREEN, D. W. BAILEY, E. L. GREEN, T. H. RODERICK, and E. S. RUSSELL (1985)
Science 230, 1407-1408
   PDF »
Rapid Mutations in Mice?.
W. M. FITCH and W. R. ATCHLEY (1985)
Science 230, 1408-1409
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)