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Science 31 May 1985:
Vol. 228. no. 4703, pp. 1106 - 1108
DOI: 10.1126/science.2986292
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Articles

Science, Vol 228, Issue 4703, 1106-1108
Copyright © 1985 by American Association for the Advancement of Science

articles

Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure

FC Tortella and JB Long

Cerebrospinal fluid taken from rats subjected to electroshock-induced seizures and injected into the cerebral ventricles of rats that had not been shocked increased the seizure threshold of the recipients. The anticonvulsant activity of the donor cerebrospinal fluid was antagonized by opioid antagonists and enhanced by peptidase inhibitors. These results suggest the existence of an endogenous anticonvulsant substance in rat cerebrospinal fluid, possibly opioid in nature, which is activated as a consequence of a seizure and which may play a critical role in postseizure inhibition.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Upregulation of opioid receptor binding following spontaneous epileptic seizures.
A. Hammers, M.-C. Asselin, R. Hinz, I. Kitchen, D. J. Brooks, J. S. Duncan, and M. J. Koepp (2007)
Brain 130, 1009-1016
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