Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 24 May 1985:
Vol. 228. no. 4702, pp. 993 - 996
DOI: 10.1126/science.2408334
Prev | Table of Contents | Next

Articles

Science, Vol 228, Issue 4702, 993-996
Copyright © 1985 by American Association for the Advancement of Science

articles

Pancreatic secretion by nonparallel exocytosis: potential resolution of a long controversy

JW Adelson and PE Miller

The idea that pancreatic digestive enzyme secretion can occur in a nonparallel manner has been controversial because of its presumed incompatibility with the exocytosis secretory mechanism. Correlation and regression analysis of enzyme output by the rabbit pancreas after it is stimulated with cholecystokinin and chymodenin revealed that digestive enzymes are secreted in a highly linked fashion, compatible with exocytosis and with nonparallel secretion. Thus, exocytosis and nonparallel secretion are not contradictory processes, but rather nonparallel secretion is due to exocytosis from heterogeneous sources within the pancreas.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
AM67, a Secretory Component of the Guinea Pig Sperm Acrosomal Matrix, Is Related to Mouse Sperm Protein sp56 and the Complement Component 4-binding Proteins.
J. A. Foster, B. B. Friday, M. T. Maulit, C. Blobel, V. P. Winfrey, G. E. Olson, K.-S. Kim, and G. L. Gerton (1997)
J. Biol. Chem. 272, 12714-12722
   Abstract »    Full Text »    PDF »
Pancreatic zymogen granules differ markedly in protein composition.
E. Mroz and C Lechene (1986)
Science 232, 871-873
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)