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Science 3 May 1985:
Vol. 228. no. 4699, pp. 554 - 558
DOI: 10.1126/science.3838595
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Articles
Science, Vol 228, Issue 4699, 554-558
Copyright © 1985 by American Association for the Advancement of Science
Insertion mutagenesis of embryonal carcinoma cells by retroviruses
W King,
MD Patel,
LI Lobel,
SP Goff,
and
MC Nguyen-Huu
Mutagenesis was studied in cultured F9 embryonal carcinoma cells infected with a variant of Moloney murine leukemia virus. Proviral insertion induced the inactivation of the hypoxanthine phosphoribosyltransferase locus, and the virus was used to isolate the mutated genes rapidly. Mutagenesis by these methods may be useful for the genetic dissection of the various mammalian cell phenotypes.
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