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Science 26 April 1985:
Vol. 228. no. 4698, pp. 492 - 495
DOI: 10.1126/science.2858917
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Articles

Science, Vol 228, Issue 4698, 492-495
Copyright © 1985 by American Association for the Advancement of Science

articles

Two types of somatostatin receptors differentiated by cyclic somatostatin analogs

VT Tran, MF Beal, and JB Martin

Somatostatin receptors in rat brain, pituitary, and pancreas were labeled with two radioiodinated analogs of somatostatins 14 and 28. Two cyclic analogs of somatostatin, SMS201-995 and cyclo(Ala-Cys-Phe-D-Trp-Lys-Thr-Cys), showed biphasic displacement of binding to somatostatin receptors by these radioligands. In contrast, all other somatostatin analogs, including somatostatin-14, competed for the receptor sites with monophasic displacement of radioligand receptor binding. Thus two types of somatostatin receptors were identified. It was found that the pituitary and pancreas have predominantly one type of somatostatin receptor whereas the brain has both, and that different regions of the brain have various proportions of the two types. These findings suggest methods to characterize other types of somatostatin receptors subserving somatostatin's diverse physiological functions, including a potential role in cognitive function and extrapyramidal motor system control.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Somatostatin Inhibits Excitatory Transmission at Rat Hippocampal Synapses via Presynaptic Receptors.
S. Boehm and H. Betz (1997)
J. Neurosci. 17, 4066-4075
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Peptide-dopamine interactions in the central nervous system: implications for neuropsychiatric disorders.
A.J. Stoessl (1989)
J Psychopharmacol 3, 99-120
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Reduced numbers of somatostatin receptors in the cerebral cortex in Alzheimer's disease.
M. Beal, M. Mazurek, V. Tran, G Chattha, E. Bird, and J. Martin (1985)
Science 229, 289-291
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