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Science 19 April 1985:
Vol. 228. no. 4697, pp. 325 - 327
DOI: 10.1126/science.3983632
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Articles

Science, Vol 228, Issue 4697, 325-327
Copyright © 1985 by American Association for the Advancement of Science

articles

Leukotriene C4 transport by the choroid plexus in vitro

R Spector and EJ Goetzl

Nanomolar concentrations of peptidoleukotrienes evoke sustained cerebral edema and arterial constriction. Peptidoleukotrienes are thus considered to play an important role in eliciting cerebral edema after cerebral ischemia and vasospasm after subarachnoid hemorrhage. It was hypothesized that the choroid plexus, the locus of the blood-cerebrospinal fluid barrier, might minimize the vasoactivity of locally generated or systemically derived leukotrienes by transporting leukotrienes from cerebrospinal fluid into the blood. Consistent with this hypothesis, leukotriene C4 in vitro was transported into and released from isolated rabbit choroid plexus by a system that was specific, energy-dependent, probenecid-sensitive, and depressed by cold temperatures. The accumulation of leukotriene C4 in the choroid plexus was not dependent on tissue binding or metabolism of leukotriene C4.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Demonstration of a Coupled Metabolism-Efflux Process at the Choroid Plexus as a Mechanism of Brain Protection Toward Xenobiotics.
N. Strazielle and J.-F. Ghersi-Egea (1999)
J. Neurosci. 19, 6275-6289
   Abstract »    Full Text »    PDF »
Transepithelial Transport of Organic Anions across the Choroid Plexus: Possible Involvement of Organic Anion Transporter and Multidrug Resistance-Associated Protein.
J.-i. Nishino, H. Suzuki, D. Sugiyama, T. Kitazawa, K. Ito, M. Hanano, and Y. Sugiyama (1999)
J. Pharmacol. Exp. Ther. 290, 289-294
   Abstract »    Full Text »


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