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Science 5 April 1985:
Vol. 228. no. 4695, pp. 89 - 91
DOI: 10.1126/science.3975633
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Articles

Science, Vol 228, Issue 4695, 89-91
Copyright © 1985 by American Association for the Advancement of Science

articles

Genotoxicity of formaldehyde in cultured human bronchial fibroblasts

RC Grafstrom, RD Curren, LL Yang, and CC Harris

Formaldehyde, a common environmental pollutant, inhibits repair of O6-methylguanine and potentiates the mutagenicity of an alkylating agent, N-methyl-N-nitrosourea, in normal human fibroblasts. Because formaldehyde alone also causes mutations in human cells, the compound may cause genotoxicity by a dual mechanism of directly damaging DNA and inhibiting repair of mutagenic and carcinogenic DNA lesions caused by other chemical and physical carcinogens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sensitivity Analysis of Biologically Motivated Model for Formaldehyde-Induced Respiratory Cancer in Humans.
K. S. Crump, C. Chen, J. F. Fox, C. Van Landingham, and R. Subramaniam (2008)
Ann. Hyg. 52, 481-495
   Abstract »    Full Text »    PDF »
Annual Review of Cosmetic Ingredient Safety Assessments--2004/2005.
(2006)
International Journal of Toxicology 25, 1-89
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Expression of Alcohol Dehydrogenase 3 in Tissue and Cultured Cells from Human Oral Mucosa.
J. J. Hedberg, J.-O. Hoog, J. A. Nilsson, Z. Xi, A. Elfwing, and R. C. Grafstrom (2000)
Am. J. Pathol. 157, 1745-1755
   Abstract »    Full Text »    PDF »
Intercellular Communication in Bronchial Epithelial Cells: Review of Evidence for a Possible Role in Lung Carcinogenesis.
C. D. Albright, R. T. Jones, P. M. Grimley, and J. H. Resau (1990)
Toxicol Pathol 18, 324-343
   Abstract »    PDF »


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