Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 March 1985:
Vol. 227. no. 4694, pp. 1580 - 1583
DOI: 10.1126/science.3975627
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4694, 1580-1583
Copyright © 1985 by American Association for the Advancement of Science

articles

Blood-brain barrier: endogenous modulation by adrenal-cortical function

JB Long and JW Holaday

The blood-brain barrier restricts the passage of molecules from the blood to the brain. The permeability of the barrier to iodine-125-labeled bovine serum albumin was examined in rats that had undergone adrenalectomy, adrenal demedullation, and corticosterone replacement. Adrenalectomy, but not adrenal demedullation, increased the permeability of brain tissue to the isotopically labeled macromolecule; corticosterone replacement reversed this effect. These results indicate that the blood-brain barrier may be hormonally regulated; that is, the pituitary-adrenal axis may physiologically modulate the permeability of the brain microvasculature to macromolecules.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Exposure to a Dysfunctional Glucocorticoid Receptor from Early Embryonic Life Programs the Resistance to Experimental Autoimmune Encephalomyelitis Via Nitric Oxide-Induced Immunosuppression.
B. Marchetti, M. C. Morale, J. Brouwer, C. Tirolo, N. Testa, S. Caniglia, N. Barden, S. Amor, P. A. Smith, and C. D. Dijkstra (2002)
J. Immunol. 168, 5848-5859
   Abstract »    Full Text »    PDF »
Effects of postnatal dexamethasone on blood-brain barrier permeability and brain water content in newborn lambs.
G. D. Sysyn, K. H. Petersson, C. S. Patlak, G. B. Sadowska, and B. S. Stonestreet (2001)
Am J Physiol Regulatory Integrative Comp Physiol 280, R547-R553
   Abstract »    Full Text »    PDF »
Exogenous and endogenous corticosteroids modulate blood-brain barrier development in the ovine fetus.
B. S. Stonestreet, G. B. Sadowska, A. J. McKnight, C. Patlak, and K. H. Petersson (2000)
Am J Physiol Regulatory Integrative Comp Physiol 279, R468-R477
   Abstract »    Full Text »    PDF »
Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus.
B. S. Stonestreet, K. H. Petersson, G. B. Sadowska, K. D. Pettigrew, and C. S. Patlak (1999)
Am J Physiol Regulatory Integrative Comp Physiol 276, R283-R289
   Abstract »    Full Text »    PDF »
.
M. Marinelli, F. Rougé-Pont, V. Deroche, M. Barrot, C. De Jésus-Oliveira, M. Le Moal, and P. V. Piazza (1997)
J. Pharmacol. Exp. Ther. 281, 1392-1400
   Abstract »    Full Text »
Prenatal and Perinatal Risk and Protective Factors for Neonatal Intracranial Hemorrhage.
S. Shankaran, C. R. Bauer, R. Bain, L. L. Wright, and J. Zachary (1996)
Arch Pediatr Adolesc Med 150, 491-497
   Abstract »    PDF »
Inhibition of Inducible Nitric Oxide Synthase Prevents Myocardial and Systemic Vascular Barrier Dysfunction During Early Cardiac Allograft Rejection.
N. K. Worrall, K. Chang, G. M. Suau, W. S. Allison, T. P. Misko, P. M. Sullivan, R. G. Tilton, J. R. Williamson, and T. B. Ferguson Jr (1996)
Circ. Res. 78, 769-779
   Abstract »    Full Text »
{alpha}2-Adrenergic Receptor Function in Depression: The Cortisol Response to Yohimbine.
L. H. Price, D. S. Charney, A. L. Rubin, and G. R. Heninger (1986)
Arch Gen Psychiatry 43, 849-858
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)