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Science 22 March 1985:
Vol. 227. no. 4693, pp. 1477 - 1479
DOI: 10.1126/science.3883488

Articles

Science, Vol 227, Issue 4693, 1477-1479
Copyright © 1985 by American Association for the Advancement of Science


articles

Flow effects on prostacyclin production by cultured human endothelial cells

JA Frangos, SG Eskin, LV McIntire, and CL Ives

Endothelial cell functions, such as arachidonic acid metabolism, may be modulated by membrane stresses induced by blood flow. The production of prostacyclin by primary human endothelial cell cultures subjected to pulsatile and steady flow shear stress was measured. The onset of flow led to a sudden increase in prostacyclin production, which decreased to a steady rate within several minutes. The steady-state production rate of cells subjected to pulsatile shear stress was more than twice that of cells exposed to steady shear stress and 16 times greater than that of cells in stationary culture.


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Cardiovasc Res 45, 27-35
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In the Femoral Artery Bifurcation, Differences in Mean Wall Shear Stress Within Subjects Are Associated With Different Intima-Media Thicknesses.
L. Kornet, A. P. G. Hoeks, J. Lambregts, and R. S. Reneman (1999)
Arterioscler Thromb Vasc Biol 19, 2933-2939
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Contribution of Vasodilator Prostanoids and Nitric Oxide to Resting Flow, Metabolic Vasodilation, and Flow-Mediated Dilation in Human Coronary Circulation.
S. J. Duffy, S. F. Castle, R. W. Harper, and I. T. Meredith (1999)
Circulation 100, 1951-1957
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Focal Expression of Angiotensin II Type 1 Receptor and Smooth Muscle Cell Proliferation in the Neointima of Experimental Vein Grafts : Relation to Eddy Blood Flow.
S. Q. Liu (1999)
Arterioscler Thromb Vasc Biol 19, 2630-2639
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Adrenal Capillary Endothelial Cells Stimulate Aldosterone Release through a Protein That Is Distinct from Endothelin.
L. J. Rosolowsky, C. J. Hanke, and W. B. Campbell (1999)
Endocrinology 140, 4411-4418
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Localization of Atherosclerosis: Role of Hemodynamics.
S. G. Frangos, V. Gahtan, and B. Sumpio (1999)
Arch Surg 134, 1142-1149
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Disturbed microvascular reactivity and shunting - a major cause for diabetic complications.
B. Fagrell, G. Jorneskog, and M. Intaglietta (1999)
Vascular Medicine 4, 125-127
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Mechanotransduction in Response to Shear Stress. ROLES OF RECEPTOR TYROSINE KINASES, INTEGRINS, AND Shc.
K.-D. Chen, Y.-S. Li, M. Kim, S. Li, S. Yuan, S. Chien, and J. Y-J. Shyy (1999)
J. Biol. Chem. 274, 18393-18400
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The Natural Course of Atherosclerosis : Part II: Vascular Remodeling.
S. Kiechl and J. Willeit (1999)
Arterioscler Thromb Vasc Biol 19, 1491-1498
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Endothelium-derived nitric oxide enhances the effect of intraaortic balloon pumping on diastolic coronary flow.
E. Toyota, M. Goto, H. Nakamoto, J. Ebata, H. Tachibana, O. Hiramatsu, Y. Ogasawara, and F. Kajiya (1999)
Ann. Thorac. Surg. 67, 1254-1261
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Modulation of Ras/Raf/Extracellular Signal–Regulated Kinase Pathway by Reactive Oxygen Species Is Involved in Cyclic Strain–Induced Early Growth Response-1 Gene Expression in Endothelial Cells.
B. S. Wung, J. J. Cheng, Y. J. Chao, H. J. Hsieh, and D. L. Wang (1999)
Circ. Res. 84, 804-812
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Temporal Gradient in Shear But Not Steady Shear Stress Induces PDGF-A and MCP-1 Expression in Endothelial Cells : Role of NO, NF{kappa}B, and egr-1.
X. Bao, C. Lu, and J. A. Frangos (1999)
Arterioscler Thromb Vasc Biol 19, 996-1003
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Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS.
L.-H. Yeh, Y. J. Park, R. J. Hansalia, I. S. Ahmed, S. S. Deshpande, P. J. Goldschmidt-Clermont, K. Irani, and B. R. Alevriadou (1999)
Am J Physiol Cell Physiol 276, C838-C847
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