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Science 15 March 1985:
Vol. 227. no. 4692, pp. 1343 - 1345
DOI: 10.1126/science.2983422
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Articles

Science, Vol 227, Issue 4692, 1343-1345
Copyright © 1985 by American Association for the Advancement of Science

articles

Interaction of calcitonin and calcitonin gene-related peptide at receptor sites in target tissues

D Goltzman and J Mitchell

Discrete receptor sites for calcitonin (CT) and calcitonin gene-related peptide (CGRP) were found in the nervous system and in peripheral tissues. Each peptide was capable of cross-reacting with the specific receptor of the other. In contrast to CT receptors, CGRP receptors were not linked to adenylate cyclase. However, CGRP could stimulate adenylate cyclase in CT target tissues apparently by interacting with CT receptors. The relative abilities of CGRP and mammalian CT to inhibit CT binding suggest that CGRP could serve as an endogenous ligand for CT receptors in the central nervous system.


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Procalcitonin and the Calcitonin Gene Family of Peptides in Inflammation, Infection, and Sepsis: A Journey from Calcitonin Back to Its Precursors.
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The Porcine Calcitonin Receptor Promoter Directs Expression of a Linked Reporter Gene in a Tissue and Developmental Specific Manner in Transgenic Mice.
C. Jagger, A. Gallagher, T. Chambers, and M. Pondel (1999)
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Central CGRP inhibits pancreatic enzyme secretion by modulation of vagal parasympathetic outflow.
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Am J Physiol Gastrointest Liver Physiol 275, G957-G963
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Activation of Phospholipase C-beta 1 via Galpha q/11 during Calcium Mobilization by Calcitonin Gene-related Peptide.
H. Drissi, F. Lasmoles, V. Le Mellay, P. J. Marie, and M. Lieberherr (1998)
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Calcitonin Gene-Related Peptide Stimulates Potassium Efflux through Adenosine Triphosphate-Sensitive Potassium Channels and Produces Membrane Hyperpolarization in Osteoblastic UMR106 Cells.
T. Kawase and D. M. Burns (1998)
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Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats.
M. Saita, A. Shimokawa, T. Kunitake, K. Kato, T. Hanamori, K. Kitamura, T. Eto, and H. Kannan (1998)
Am J Physiol Regulatory Integrative Comp Physiol 274, R979-R984
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Calcitonin Increases Cytosolic Free Calcium Concentration via Capacitative Calcium Influx.
A. Teti, R. Paniccia, and S. R. Goldring (1995)
J. Biol. Chem. 270, 16666-16670
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Plethysmographic Evaluation of the Vascular Effects of Human Calcitonin Gene-Related Peptide in Man.
C. Gennari, R. Nami, S. Pecchi, V. De Franco, F. Panza, and G. Pavese (1991)
Angiology 42, 462-467
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