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Science 8 March 1985:
Vol. 227. no. 4691, pp. 1238 - 1240
DOI: 10.1126/science.2983420
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Articles

Science, Vol 227, Issue 4691, 1238-1240
Copyright © 1985 by American Association for the Advancement of Science

articles

A second nuclear protein is encoded by Epstein-Barr virus in latent infection

K Hennessy and E Kieff

A region of the Epstein-Barr virus (EBV) genome that is important in inducing cell proliferation includes a single long open reading frame. Part of this open reading frame has been fused to the lacZ gene and expressed in Escherichia coli. Antisera to the fusion protein identify a protein in the nuclei of latently infected growth-transformed lymphocytes and in Burkitt tumor cells grown in vitro. This nuclear protein is encoded by a different virus-gene than that which encodes the previously described EBV nuclear antigen, EBNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Epstein-Barr Virus and Cancer.
M. P. Thompson and R. Kurzrock (2004)
Clin. Cancer Res. 10, 803-821
   Abstract »    Full Text »    PDF »
A repetitive sequence of Epstein-Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4+ T lymphocytes.
E. Rajnavolgyi, N. Nagy, B. Thuresson, Z. Dosztanyi, A. Simon, I. Simon, R. W. Karr, I. Ernberg, E. Klein, and K. I. Falk (2000)
Int. Immunol. 12, 281-293
   Abstract »    Full Text »    PDF »


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