Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 1 March 1985:
Vol. 227. no. 4690, pp. 1054 - 1056
DOI: 10.1126/science.3975601

Articles

Science, Vol 227, Issue 4690, 1054-1056
Copyright © 1985 by American Association for the Advancement of Science


articles

Limits of neurogenesis in primates

P Rakic

Systematic analysis of autoradiograms prepared from postpubertal rhesus monkeys given single and multiple injections of tritium-labeled thymidine and killed 3 days to 6 years later displayed a slow turnover of glial cells but failed to reveal any radiolabeled neurons. Therefore, unlike neurons of some nonprimate species, all neurons of the rhesus monkey brain are generated during prenatal and early postnatal life. A stable population of neurons in primates, including humans, may be important for the continuity of learning and memory over a lifetime.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Excitatory GABAergic Activation of Cortical Dividing Glial Cells.
Y. Tanaka, Y. Tozuka, T. Takata, N. Shimazu, N. Matsumura, A. Ohta, and T. Hisatsune (2009)
Cereb Cortex 19, 2181-2195
   Abstract »    Full Text »    PDF »
Nonselective Sister Chromatid Segregation in Mouse Embryonic Neocortical Precursor Cells.
J.-F. Fei and W. B. Huttner (2009)
Cereb Cortex 19, i49-i54
   Abstract »    Full Text »    PDF »
Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling.
J. J. Breunig, M. R. Sarkisian, J. I. Arellano, Y. M. Morozov, A. E. Ayoub, S. Sojitra, B. Wang, R. A. Flavell, P. Rakic, and T. Town (2008)
PNAS 105, 13127-13132
   Abstract »    Full Text »    PDF »
Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease.
P. Thomas and M. Fenech (2008)
Mutagenesis 23, 57-65
   Abstract »    Full Text »    PDF »
Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus.
J. J. Breunig, J. Silbereis, F. M. Vaccarino, N. Sestan, and P. Rakic (2007)
PNAS 104, 20558-20563
   Abstract »    Full Text »    PDF »
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells.
U Shivraj Sohur, J. G Emsley, B. D Mitchell, and J. D Macklis (2006)
Phil Trans R Soc B 361, 1477-1497
   Abstract »    Full Text »    PDF »
From the Cover: Neocortical neurogenesis in humans is restricted to development.
R. D. Bhardwaj, M. A. Curtis, K. L. Spalding, B. A. Buchholz, D. Fink, T. Bjork-Eriksson, C. Nordborg, F. H. Gage, H. Druid, P. S. Eriksson, et al. (2006)
PNAS 103, 12564-12568
   Abstract »    Full Text »    PDF »
Stable neuron numbers from cradle to grave.
R. S. Nowakowski (2006)
PNAS 103, 12219-12220
   Full Text »    PDF »
The postnatal development of neocortical neurons and glial cells in the Gottingen minipig and the domestic pig brain.
J. Jelsing, R. Nielsen, A. K. Olsen, N. Grand, R. Hemmingsen, and B. Pakkenberg (2006)
J. Exp. Biol. 209, 1454-1462
   Abstract »    Full Text »    PDF »
Cerebellum- and forebrain-derived stem cells possess intrinsic regional character.
C. Klein, S. J. B. Butt, R. P. Machold, J. E. Johnson, and G. Fishell (2005)
Development 132, 4497-4508
   Abstract »    Full Text »    PDF »
Adult Neurogenesis: From Precursors to Network and Physiology.
D. N. Abrous, M. Koehl, and M. Le Moal (2005)
Physiol Rev 85, 523-569
   Abstract »    Full Text »    PDF »
Nonrenewal of Neurons in the Cerebral Neocortex of Adult Macaque Monkeys.
D. Koketsu, A. Mikami, Y. Miyamoto, and T. Hisatsune (2003)
J. Neurosci. 23, 937-942
   Abstract »    Full Text »    PDF »
Cerebral Capillary Endothelial Cell Mitogenesis and Morphogenesis Induced by Astrocytic Epoxyeicosatrienoic Acid.
C. Zhang and D. R. Harder (2002)
Stroke 33, 2957-2964
   Abstract »    Full Text »    PDF »
Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke.
S. L. Small, P. Hlustik, D. C. Noll, C. Genovese, and A. Solodkin (2002)
Brain 125, 1544-1557
   Abstract »    Full Text »    PDF »
Adolescents who were born very preterm have decreased brain volumes.
C. Nosarti, M. H. S. Al-Asady, S. Frangou, A. L. Stewart, L. Rifkin, and R. M. Murray (2002)
Brain 125, 1616-1623
   Abstract »    Full Text »    PDF »
Cell Proliferation Without Neurogenesis in Adult Primate Neocortex.
D. R. Kornack and P. Rakic (2001)
Science 294, 2127-2130
   Abstract »    Full Text »    PDF »
Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus.
L. S. Shihabuddin, P. J. Horner, J. Ray, and F. H. Gage (2000)
J. Neurosci. 20, 8727-8735
   Abstract »    Full Text »    PDF »
Comparative Views of Adult Neurogenesis.
N. B. Hastings, P. Tanapat, and E. Gould (2000)
Neuroscientist 6, 315-325
   Abstract »    PDF »
Exploiting Nonneural Cells to Rebuild the Nervous System: From Bone Marrow to Brain.
S. A. Azizi (2000)
Neuroscientist 6, 353-361
   Abstract »    PDF »
New Neurons: Extraordinary Evidence or Extraordinary Conclusion?.
R. S. Nowakowski, N. L. Hayes;, E. Gould, and C. G. Gross; (2000)
Science 288, 771a-771
   Full Text »
Neurogenesis in the Neocortex of Adult Primates.
E. Gould, A. J. Reeves, M. S. Graziano, and C. G. Gross (1999)
Science 286, 548-552
   Abstract »    Full Text »
Continuation of neurogenesis in the hippocampus of the adult macaque monkey.
D. R. Kornack and P. Rakic (1999)
PNAS 96, 5768-5773
   Abstract »    Full Text »    PDF »
Hippocampal neurogenesis in adult Old World primates.
E. Gould, A. J. Reeves, M. Fallah, P. Tanapat, C. G. Gross, and E. Fuchs (1999)
PNAS 96, 5263-5267
   Abstract »    Full Text »    PDF »
Neurogenesis, cell death and regeneration in the adult gymnotiform brain.
G. Zupanc (1999)
J. Exp. Biol. 202, 1435-1446
   Abstract »    PDF »
Bcl-2 Protein as a Marker of Neuronal Immaturity in Postnatal Primate Brain.
P. J. Bernier and A. Parent (1998)
J. Neurosci. 18, 2486-2497
   Abstract »    Full Text »    PDF »
Genetic influence on neurogenesis in the dentate gyrus of adult mice.
G. Kempermann, H. G. Kuhn, and F. H. Gage (1997)
PNAS 94, 10409-10414
   Abstract »    Full Text »    PDF »
Long-distance neuronal migration in the adult mammalian brain.
C Lois and A Alvarez-Buylla (1994)
Science 264, 1145-1148
   Abstract »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)