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Science 1 March 1985:
Vol. 227. no. 4690, pp. 1049 - 1051
DOI: 10.1126/science.3883485
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Articles

Science, Vol 227, Issue 4690, 1049-1051
Copyright © 1985 by American Association for the Advancement of Science

articles

Distribution of enkephalin immunoreactivity in germinative cells of developing rat cerebellum

IS Zagon, RE Rhodes, and PJ McLaughlin

The cellular distribution of enkephalin, an endogenous opioid, in the developing rat cerebellum was determined by immunocytochemistry. Methionine and leucine enkephalin were concentrated in the external germinal layer, a matrix of proliferative cells; staining was confined to the cortical cytoplasm. Enkephalin was not detected by immunocytochemistry in differentiated neural cells. These results indicate that endogenous opioids are involved specifically in early phases of nervous system development, particularly cell proliferation and differentiation.


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Atrial Natriuretic Peptide-like Immunoreactivity in Neurons and Astrocytes of Human Cerebellum and Inferior Olivary Complex.
J. C. McKenzie, Y.-W. Juan, C. R. Thomas, N. E.J. Berman, and R. M. Klein (2001)
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Opioid Peptide Gene Expression Primes Cardiogenesis in Embryonal Pluripotent Stem Cells.
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Elf-pulsed magnetic fields modulate opioid peptide gene expression in myocardial cells.
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Localization of preproenkephalin mRNA in rat heart: selective gene expression in left ventricular myocardium.
J. Weil, T. Eschenhagen, G. Fleige, C. Mittmann, E. Orthey, and H. Scholz (1998)
Am J Physiol Heart Circ Physiol 275, H378-H384
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Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster. I. REGULATION OF PRODYNORPHIN GENE EXPRESSION BY NUCLEAR PROTEIN KINASE C.
C. Ventura, G. Pintus, M. G. Fiori, F. Bennardini, G. Pinna, and L. Gaspa (1997)
J. Biol. Chem. 272, 6685-6692
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Opioid Peptide Gene Expression in the Primary Hereditary Cardiomyopathy of the Syrian Hamster. III. AUTOCRINE STIMULATION OF PRODYNORPHIN GENE EXPRESSION BY DYNORPHIN B.
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Phorbol Ester Regulation of Opioid Peptide Gene Expression in Myocardial Cells.
C. Ventura, G. Pintus, I. Vaona, F. Bennardini, G. Pinna, and B. Tadolini (1995)
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Brain region and gene specificity of neuropeptide gene expression in cultured astrocytes.
H Shinoda, A. Marini, C Cosi, and J. Schwartz (1989)
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