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Science 15 February 1985:
Vol. 227. no. 4688, pp. 770 - 773
DOI: 10.1126/science.3155875
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Articles

Science, Vol 227, Issue 4688, 770-773
Copyright © 1985 by American Association for the Advancement of Science

articles

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

GA Graveland, RS Williams, and M DiFiglia

Golgi impregnations of neostriatum from deceased Huntington's disease patients and controls were examined. In all cases of Huntington's disease the morphology of dendrites of medium-sized spiny neurons was markedly altered by the appearance of recurved endings and appendages, a decrease or increase in the density of spines, and abnormalities in the size and shape of spines. Pathological changes were rarely observed in medium-sized and large aspiny neostriatal neurons. The findings provide evidence for simultaneous degeneration and growth of spiny neurons in Huntington's disease and support the view that a specific population of neostriatal neurons is selectively involved in its pathogenesis.


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